Compatibility «Alimta» and «Valusal»

• Interactions Alimta with Valusal

  • Dangerous interactions
    • ⓘ Patients with mild to moderate renal insufficiency should not use NSAIDs with a short 1/2'>T_{1/2 for 2 days before the use of pemetrexed, on the day of application and for 2 days after application.}
    • ⓘ In patients with mild or moderate renal insufficiency (creatinine clearance from 45 to 79 ml/min), concomitant use of pemetrexed with NSAIDs in high doses should be avoided for two days before the use of pemetrexed, on the day of use and for two days after the use of pemetrexed (see section 'Special instructions').
  • Negative interactions
    • ⓘ If co-administration of NSAIDs is required, strict toxicity control is necessary, especially with regard to myelosuppression and gastrointestinal toxicity.
    • ⓘ In patients with normal renal function (creatinine clearance ≥80 ml/min), the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in high doses (for example, ibuprofen >1600 mg /day or acetylsalicylic acid ≥1.3 g / day) may lead to a decrease in the clearance of pemetrexed and, as a result, increase the frequency of adverse events when used pemetrexed.
    • ⓘ NSAIDs should be used with caution in high doses simultaneously with pemetrexed in patients with normal renal function (creatinine clearance ≥80 ml/min).
    • ⓘ Due to the lack of data on a possible interaction between pemetrexed and NSAIDs with a long half-life, such as piroxicam or rofecoxib, the simultaneous use of these drugs with pemetrexed in patients with mild or moderate renal insufficiency should be discontinued for the next period of time: at least five days before the administration of pemetrexed, on the day of administration and for at least two days after the administration of pemetrexed (see the section 'Special instructions').
    • ⓘ If the combined use of NSAIDs and pemetrexed is required, patients should be strictly monitored for manifestations of toxicity, especially myelosuppression and gastrointestinal toxicity.
    • ⓘ Myelotoxic drugs enhance the manifestations of hematotoxicity.
  • No interactions
    • ⓘ Due to the lack of data on the possible interaction between pemetrexed and NSAIDs with long-term 1/2'>T_1/2, all patients taking NSAIDs should discontinue NSAID treatment at least 5 days before, on the day of admission and within 2 days after the use of pemetrexed.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,999,821 possible combinations of drugs and their components were found 412,536 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-02-20

Category - medicine