Compatibility «Drospirenone+Ethinylestradiol» and «Dexamethasone»
Between «Drospirenone+Ethinylestradiol» and «Dexamethasone» found 1 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Dexamethasone |
✘Drospirenone+Ethinylestradiol [Ethinylestradiol and more 1Drospirenone] Analogs | |
✘Dexamethasone [Ethinylestradiol and more 1Drospirenone] Analogs |
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Interactions Drospirenone+Ethinylestradiol with Dexamethasone
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Dangerous interactions
Reduce the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), enhance - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin In and carbonic anhydrase inhibitors, the risk of erosive ulcerative lesions and bleeding from the gastrointestinal tract - NSAIDs. -
Negative interactions
In clinical studies, the use of a hormonal contraceptive containing ethinyl estradiol did not lead to an increase or led only to a slight increase in the concentration of CYP3A4 substrates in blood plasma (for example, midazolam), while the concentration of CYP1A2 substrates in blood plasma may increase slightly (for example, theophylline) or moderately (for example, melatonin and tizanidine). Two additional clinical drug interaction studies using simvastatin and midazolam as marker substrates for CYP3A4 were performed with 24 healthy postmenopausal women. With simultaneous use, the condition of patients should be monitored for signs of a decrease in the clinical effects of estrogens (for example, breakthrough bleeding), oral contraceptives or combined non-oral contraceptives. The use of estrogens is associated with an increase in serum concentrations of corticosteroid-binding globulin, which leads to an increase in the total number of circulating GCS, although the free concentrations of these hormones may be lower, the clinical significance of this phenomenon is unknown. Due to the induction of CYP3A4 by dexamethasone, it is possible to reduce the clinical effectiveness of estrogens. -
No interactions
In vitro studies, drospirenone did not affect the metabolism of model substrates involving CYP1A2 and CYP2D6, but inhibited the metabolism of CYP1A1, CYP2C9, CYP2C19 and CYP3A4 substrates, with CYP2C19 proving to be the most sensitive enzyme. The results of these studies demonstrated that the pharmacokinetics of CYP3A4 substrates were not affected by ss'>Css drospirenone achieved after its administration at a dose of 3 mg/day. -
Unclear interactions
Strong and moderate CYP3A4 inhibitors such as azole antifungal drugs (e.g. ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g. clarithromycin, erythromycin), diltiazem and grapefruit juice may increase the concentration of estrogen or progestin, or both components, in blood plasma. ГКС. The potential effect of drospirenone on the activity of CYP2C19 and CYP3A4 has been studied in clinical pharmacokinetic studies using omeprazole, simvastatin and midazolam as marker substrates. In vitro, ethinyl estradiol is a reversible inhibitor of CYP2C19, CYP1A1 and CYP1A2, as well as, by mechanism of action, an inhibitor of CYP3A4/5, CYP2C8 and CYP2J2. Estrogens.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine