Compatibility «Prednisolone» and «Budesonid-nativ»
Between «Prednisolone» and «Budesonid-nativ» found 3 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Budesonid-nativ |
✘Prednisolone Analogs | |
✘Budesonid-nativ [Budesonide] Analogs |
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Interactions Prednisolone with Budesonid-nativ
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Dangerous interactions
During the use of immunosuppressive doses of glucocorticoids and vaccines containing live viruses, virus replication and the development of viral diseases are possible, and antibody production is reduced (simultaneous use is not recommended). and nonsteroidal anti-inflammatory drugs (NSAIDs) - the risk of erosive and ulcerative lesions of the gastrointestinal tract and the development of bleeding increases (in combination with NSAIDs in the treatment of arthritis, it is possible to reduce the dose of GCS due to the summation of the therapeutic effect);. tricyclic antidepressants - may increase the severity of depression caused by taking GCS (not indicated for the treatment of these side effects);. -
Negative interactions
Barbiturates, antiepileptic drugs (phenytoin, carbamazepine), rifampicin accelerate the metabolism of glucocorticoids (by induction of microsomal enzymes). Hypokalemia caused by GCS can increase the severity and duration of muscle block against the background of muscle relaxants. Cytochrome P450 inhibitors (in pm ketoconazole, erythromycin, cyclosporine) can slow down metabolism and enhance the glucocorticoid effect. An increase in the effects of corticosteroids associated with an increase in their concentration in blood plasma was observed in women taking estrogens or high doses of combined oral contraceptives. Budesonide and Prednisolone belong to the same pharmaceutical group: Glucocorticosteroids. -
Positive interactions
Cytochrome CYP3A (P450) inhibitors, such as ketoconazole, itraconazole, ritonavir, troleandomycin, erythromycin, clarithromycin, cyclosporine, grapefruit juice can enhance the effect of GCS.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine