Compatibility «Indapamide» and «Hydrochlorothiazide+Telmisartan»
Between «Indapamide» and «Hydrochlorothiazide+Telmisartan» found 6 dangerous and 30 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Hydrochlorothiazide+Telmisartan |
✘Indapamide Analogs | |
✘Hydrochlorothiazide+Telmisartan [Hydrochlorothiazide and more 1Telmisartan] Analogs |
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Interactions Indapamide with Hydrochlorothiazide+Telmisartan
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Dangerous interactions
In elderly patients, patients with dehydration (including those taking diuretics) or impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm telmisartan, may lead to deterioration of renal function, including possible acute renal failure. Hypokalemia and hypomagnesemia caused by the action of thiazide diuretics increase the toxicity of cardiac glycosides. Dehydration of the body while taking thiazide diuretics increases the risk of acute renal failure, especially when using high doses of iodine-containing contrast agents. Indapamide (C03BA11) + Thiazide diuretics (C03A) => Increases the likelihood of hypokalemia. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown). It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. Previous therapy with high-dose diuretics, including furosemide (a 'loop' diuretic), may lead to a decrease in BCC and an increased risk of arterial hypotension at the beginning of telmisartan therapy. -
Negative interactions
An increase in serum lithium concentration and lithium toxicity has been reported when used concomitantly with thiazide diuretics or ARA II, including telmisartan. The use of NSAIDs, including selective COX-2 inhibitors, can reduce the diuretic, natriuretic and antihypertensive effects of diuretics. Therefore, when using a combination of hydrochlorothiazide + telmisartan and NSAIDs, including selective COX-2 inhibitors, it is necessary to carefully monitor to determine whether the desired effect of the diuretic is achieved. Other antihypertensive drugs. It may be necessary to adjust the dose of simultaneously prescribed antihypertensive drugs. Thiazide diuretics affect glucose tolerance (hyperglycemia may develop) and reduce the effectiveness of hypoglycemic agents (dose adjustment of hypoglycemic agents may be required). Concomitant use of thiazide diuretics (including hydrochlorothiazide) with beta-blockers or diazoxide may increase the risk of hyperglycemia. Thiazide diuretics may increase the frequency of hypersensitivity reactions to allopurinol. Thiazide diuretics (including hydrochlorothiazide) can reduce the clearance of amantadine, lead to an increase in the concentration of amantadine in blood plasma and increase the risk of its undesirable effects. Anticholinergic drugs (for example, atropine, biperiden) increase the bioavailability of thiazide diuretics by reducing gastrointestinal motility and gastric emptying rate. Thiazide diuretics reduce the renal excretion of cytotoxic drugs (e.g. cyclophosphamide and methotrexate) and potentiate their myelosuppressive effect. With the simultaneous use of thiazide diuretics and cyclosporine, the risk of hyperuricemia and exacerbation of gout increases. Thiazide diuretics may reduce the effect of oral anticoagulants. ARA II, such as telmisartan, reduce diuretic-induced potassium loss. Previous treatment with high doses of diuretics such as furosemide (loop diuretic) and hydrochlorothiazide (thiazide diuretic) may lead to hypovolemia and risk of hypotension at the beginning of treatment with telmisartan. Other antihypertensive agents. Based on the pharmacological properties of baclofen and amifostine, it can be assumed that they will enhance the therapeutic effect of all antihypertensive drugs, including telmisartan. The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs. In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy. Indapamide and Hydrochlorothiazide belong to the same pharmaceutical group: Thiazide diuretics. Thiazides can reduce plasma levels of iodine bound to proteins. Thiazides should be discontinued before parathyroid function tests are performed. Concomitant use of thiazide diuretics (including hydrochlorothiazide), with beta‑blockers or diazoxide may increase the risk of hyperglycemia. It may be necessary to adjust the dose of uricosuric drugs, since hydrochlorothiazide increases the concentration of uric acid in the blood serum. Thiazide diuretics may increase the frequency of hypersensitivity reactions to allopurinol. Anticholinergic drugs (for example, atropine, biperiden) increase the bioavailability of thiazide diuretics by reducing the motility of the gastrointestinal tract and the rate of gastric emptying. Dehydration of the body while taking thiazide diuretics increases the risk. Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted. ARA II, such as telmisartan, reduces potassium loss caused by diuretics. The effect of telmisartan on lowering blood pressure can be enhanced by simultaneous administration of other antihypertensive medications. Based on their pharmacological properties, it can be expected that the following drugs can enhance the antihypertensive effect of all antihypertensive agents, including telmisartan: baclofen, amifostin. -
Positive interactions
When used concomitantly with thiazide diuretics, hyponatremia may be potentiated. The effect of telmisartan may be enhanced when used concomitantly with other antihypertensive drugs. -
Unclear interactions
Diuretics, potassium-sparing diuretics, or potassium-containing dietary supplements. Diuretics (thiazide or loop). 'Loop' and thiazide diuretics.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine