Compatibility «Zidovudine+Lamivudine» and «Fluconazole»
Between «Zidovudine+Lamivudine» and «Fluconazole» found 5 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Fluconazole |
✘Zidovudine+Lamivudine [Zidovudine and more 1Lamivudine] Analogs | |
✘Fluconazole [Zidovudine and more 1Lamivudine] Analogs |
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Interactions Zidovudine+Lamivudine with Fluconazole
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Negative interactions
With the simultaneous use of a combination of zidovudine + lamivudine with fluconazole, phenobarbital and valproic acid, it is recommended to monitor the toxic effect of zidovudine. With simultaneous use of zidovudine with fluconazole, there is an increase in max'>Cmax zidovudine by 84%, AUC by 74%, 1/2'>T1/2 is prolonged by about 128%; an increase in side effects is possible the effects of zidovudine (it may be necessary to reduce the dose of zidovudine). Zidovudine: when used concomitantly with fluconazole, there is an increase in max'>Cmax and AUC of zidovudine by 84% and 74%, respectively. Before and after therapy with fluconazole at a dose of 200 mg /day for 15 days, patients with AIDS and ARC (AIDS-related complex) showed a significant increase in the AUC of zidovudine (20%). Patients receiving this combination should be monitored to identify side effects of zidovudine. -
Unclear interactions
Fluconazole 400 mg per day.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine