Compatibility «Salmeterol+Fluticasone» and «Budesonide»
Between «Salmeterol+Fluticasone» and «Budesonide» found 1 dangerous and 10 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Budesonide |
✘Salmeterol+Fluticasone [Salmeterol and more 1Fluticasone] Analogs | |
✘Budesonide [Salmeterol and more 1Fluticasone] Analogs |
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Interactions Salmeterol+Fluticasone with Budesonide
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Dangerous interactions
Beta-adrenomimetics (R03AA) + Glucocorticosteroids => Concomitant use is contraindicated during pregnancy (may lead to pulmonary edema in the mother). -
Negative interactions
The simultaneous use of strong CYP3A4 inhibitors (for example, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with this combination is not recommended, etc; it is possible to increase the systemic level of GCS and increase cardiovascular side effects. During post-registration use, clinically significant drug interactions were reported in patients receiving fluticasone and ritonavir, which led to the development of systemic corticosteroid effects, including Cushing's syndrome and suppression of adrenal hormone secretion. Xanthine derivatives, glucocorticoids and diuretics increase the risk of hypokalemia, especially in patients with severe asthma, as well as in conditions of hypoxia (monitoring of potassium levels in blood plasma is mandatory). However, concomitant therapy with drugs that have an inhibitory effect on the CYP3A4 isoenzyme (for example, ritonavir, itraconazole, erythromycin) may lead to inhibition of GCS metabolism, which is accompanied by increased systemic effects. The degree of clinical significance of such interactions depends on the activity of the inhibitor of the CYP3A4 isoenzyme, the dose and the method of administration of GCS. As part of post-registration use, clinically significant drug interactions were observed in patients receiving fluticasone intranasally or inhaled together with ritonavir, which led to systemic effects of GCS, including Itsenko-Cushing syndrome and adrenal suppression. Except in cases where the potential benefit to the patient outweighs the possible risk of systemic side effects of GCS. Fluticasone and Budesonide belong to the same pharmaceutical group: Glucocorticosteroids. Cytochrome P450 inhibitors (in pm ketoconazole, erythromycin, cyclosporine) can slow down metabolism and enhance the glucocorticoid effect. An increase in the effects of corticosteroids associated with an increase in their concentration in blood plasma was observed in women taking estrogens or high doses of combined oral contraceptives. -
No interactions
A population pharmacokinetic analysis of nine controlled clinical trials involving 350 patients with asthma did not reveal a significant effect on the pharmacokinetics of fluticasone or salmeterol when combined with beta2short-acting agonists, methylxanthines, intranasal corticosteroids, antihistamines commonly used in patients with bronchial asthma. Compatible (simultaneous inhalation with corticosteroids and/or cromoglycic acid is possible. -
Positive interactions
Cytochrome CYP3A (P450) inhibitors, such as ketoconazole, itraconazole, ritonavir, troleandomycin, erythromycin, clarithromycin, cyclosporine, grapefruit juice can enhance the effect of GCS.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine