Compatibility «Imatinib» and «Paracetamol»
Between «Imatinib» and «Paracetamol» found 1 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Paracetamol |
✘Imatinib Analogs | |
✘Paracetamol [Paracetamol] Analogs |
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Interactions Imatinib with Paracetamol
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Dangerous interactions
Cases of fatal liver failure have also been reported when taking imatinib simultaneously with paracetamol. -
Negative interactions
In vitro, imatinib inhibits the O-glucuronidation of paracetamol (Ki=58.5 microns) at therapeutic levels. The systemic effects of paracetamol when used in combination with imatinib may increase; no special studies have been conducted, caution should be exercised. Liver function should be monitored with a combination of imatinib and hepatotoxic chemotherapy regimens. In vitro, imatinib inhibits acetaminophen/paracetamol O-glucuronidation (inhibition constant-Ki 58.5 microns). However, the use of imatinib (at a dose of 400 mg per day for 8 days) with acetaminophen/paracetamol (a single dose of 1000 mg on the eighth day) in patients with CML did not lead to a change in the pharmacokinetics of acetaminophen / paracetamol. -
No interactions
The pharmacokinetics of imatinib did not change with a single application of acetaminophen / paracetamol. There is no information on the pharmacokinetics or safety of concomitant use of imatinib at doses > 400 mg per day with acetaminophen /paracetamol or long-term simultaneous use of acetaminophen /paracetamol and imatinib.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine