Compatibility «Tamsulosin» and «Polydexa with phenylephrine»
Between «Tamsulosin» and «Polydexa with phenylephrine» found 1 dangerous and 6 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Polydexa with phenylephrine |
✘Tamsulosin Analogs | |
✘Polydexa with phenylephrine [Dexamethasone+Neomycin+Polymyxin B+Phenylephrine and more 4Dexamethasone, Neomycin, Polymyxin B, Phenylephrine] Analogs |
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Interactions Tamsulosin with Polydexa with phenylephrine
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Dangerous interactions
Since such patients are difficult to identify and there is a possibility of a significant increase in tamsulosin exposure when used in combination with strong CYP3A4 inhibitors, the combined use of tamsulosin and strong CYP3A4 inhibitors (e.g. ketoconazole) should be avoided in slow metabolizers of CYP2D6. -
Negative interactions
The effect of co-administration of a moderate CYP3A4 inhibitor (e.g. erythromycin) on the pharmacokinetics of tamsulosin has not been evaluated. Tamsulosin should be administered with caution in combination with moderate CYP3A4 inhibitors. The effect of the combined use of CYP3A4 and CYP2D6 inhibitors with tamsulosin has not been evaluated. However, there is a possibility of a significant increase in tamsulosin exposure when it is co-administered with a combination of CYP3A4 and CYP2D6 inhibitors. Alpha-blockers (phentolamine), phenothiazines, furosemide and other diuretics prevent vasoconstriction. Phenylephrine reduces the antihypertensive effect of diuretics and antihypertensive drugs, beta‑blockers (risk of hypertension and disorders of the cardiovascular system). -
Unclear interactions
Strong and moderate inhibitors of CYP3A4 or CYP2D6. Tamsulosin is intensively metabolized, mainly with the participation of CYP3A4 and CYP2D6. The effect of ketoconazole (a strong CYP3A4 inhibitor), taken at a dose of 400 mg 1 time per day for 5 days, on the pharmacokinetics of a single dose of 0.4 mg tamsulosin was evaluated in 24 healthy volunteers (23-47 years old).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine