Compatibility «Clarithromycin» and «Zidovudine+Lamivudine»
Between «Clarithromycin» and «Zidovudine+Lamivudine» found 10 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Zidovudine+Lamivudine |
✘Clarithromycin Analogs | |
✘Zidovudine+Lamivudine [Zidovudine and more 1Lamivudine] Analogs |
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Interactions Clarithromycin with Zidovudine+Lamivudine
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Negative interactions
The absorption of zidovudine decreases with simultaneous administration of clarithromycin in the form of tablets. With simultaneous oral administration of clarithromycin and zidovudine, the equilibrium concentrations of zidovudine decreased in HIV-infected adult patients. When taking 500 mg of clarithromycin twice a day, the AUC of zidovudine at steady state decreased by an average of 12% (n=4). Limited data obtained in 24 patients who took clarithromycin 2-4 hours before oral administration of zidovudine indicate that the equilibrium concentration of zidovudine (max'>Cmax) was increased by about 2 times, without changing the AUC. Similar dose adjustments should be considered in patients with reduced renal function if ritonavir is used as a pharmacokinetic 'booster' when using other HIV protease inhibitors, including atazanavir and saquinavir (see subsection 'Bidirectional drug interaction'). Simultaneous oral administration of clarithromycin and zidovudine tablets by adult HIV‑infected patients may lead to a decrease in the equilibrium concentration of zidovudine. Since clarithromycin affects the absorption of zidovudine by oral administration, interactions can be largely avoided by taking clarithromycin and zidovudine at 4-hour intervals. No such interaction was observed in HIV-infected children taking a pediatric suspension of clarithromycin with zidovudine or dideoxyinosine. Since clarithromycin can interfere with the absorption of zidovudine when taken orally at the same time in adult patients, such an interaction is unlikely to be possible when using clarithromycin intravenously. Macrolides (J01FA) + Zidovudine => Decrease in serum zidovudine concentration (especially with clarithromycin). -
Unclear interactions
Clarithromycin. It is necessary to observe the interval between doses of clarithromycin and zidovudine at least 2 hours. Zidovudine. HIV protease inhibitors. Clarithromycin 500 mg 2 times a day.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine