Compatibility «Betamethasone» and «Methylprednisolone»
Between «Betamethasone» and «Methylprednisolone» found 4 dangerous and 22 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Methylprednisolone |
✘Betamethasone Analogs | |
✘Methylprednisolone Analogs |
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Interactions Betamethasone with Methylprednisolone
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Dangerous interactions
Estrogens can reduce the hepatic metabolism of some GCS, enhancing their effect. Ketoconazole can significantly, up to 60%, reduce the metabolism of some GCS, which leads to an increased risk of their side effects. There is also an increased risk of hypokalemia with concomitant use of GCS with amphotericin B, xanthines or beta2-adrenoblockers. If possible, regular administration of vaccines or toxins should be postponed until corticosteroid therapy is discontinued. -
Negative interactions
Betamethasone and Methylprednisolone belong to the same pharmaceutical group: Glucocorticosteroids. Acetylsalicylic acid should be used with caution in combination with corticosteroids in patients with hypoprothrombinemia. Many drugs are CYP3A4 substrates, some of them alter the metabolism of GCS by induction or inhibition of CYP3A4. In the presence of another CYP3A4 substrate, a change in the hepatic clearance of methylprednisolone may require appropriate dose adjustment of GCS. CYP3A4 inducers may enhance the metabolism of GCS, and an increase in the dose of GCS may be required. There are reports of both an increase and a decrease in the effects of anticoagulants when used simultaneously with GCS. The combined use of GCS and warfarin usually leads to suppression of the reaction to warfarin, therefore, frequent monitoring of coagulation parameters should be established to maintain the desired anticoagulant effect. Drugs that induce CYP3A4 activity may enhance the metabolism of GCS, so an increase in the dose of GCS may be required. CYP3A4 inducers may enhance the metabolism of GCS, so an increase in the dose of GCS may be required. The development of acute myopathy has been reported with the simultaneous use of high doses of GCS and neuromuscular transmission blockers (see 'Precautions'). If possible, anticholinesterase drugs should be discontinued at least 24 hours before the start of GCS therapy. Since the use of GCS can cause an increase in the concentration of glucose in the blood, it may be necessary to adjust the dosage of antidiabetic drugs. Simultaneous use of CYP3A4 inhibitors may lead to an increase in the concentration of GCS in blood plasma. The dose of GCS should be titrated to avoid the development of side effects. Suppression of adrenal function by aminoglutetimide may exacerbate endocrine changes caused by prolonged use of GCS. There are reports that macrolide antibiotics cause a significant decrease in the clearance of GCS. CYP3A4 inhibitors can potentially lead to an increase in the concentration of GCS in blood plasma. With the simultaneous use of NSAIDs and GCS, the frequency of gastrointestinal bleeding and ulcers may increase. Caution should be exercised when concomitantly using acetylsalicylic acid with GCS in patients with hypoprothromboinemia. With the simultaneous use of GCS and drugs that promote potassium excretion (for example, diuretics), patients should be monitored for the development of hypokalemia. GCS can induce the metabolism of HIV protease inhibitors and cause a decrease in their concentration in blood plasma. Patients receiving long-term corticosteroid therapy may experience a decreased response to toxins and live or attenuated vaccines due to suppression of the antibody response. -
No interactions
The activity of both cyclosporine and GCS may increase with their simultaneous use. -
Positive interactions
GCS can also potentiate the reproduction of some organisms contained in live attenuated vaccines. -
Unclear interactions
Methylprednisolone is a substrate of the cytochrome P450 system and is mainly metabolized by the CYP3A4 isoenzyme, which catalyzes the 6β-hydroxylation of steroids, the main phase of metabolism of endogenous and synthetic GCS. Corticosteroids can affect the action of cholinolytics. GCS reduce the effect of anticholinesterase drugs in myasthenia gravis. HIV protease inhibitors such as indinavir and ritonavir may increase the concentration of GCS in blood plasma. GCS can suppress the reaction to skin tests.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine