Compatibility «Carbamazepine» and «Depakine chrono»
Between «Carbamazepine» and «Depakine chrono» found 1 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Depakine chrono |
✘Carbamazepine Analogs | |
✘Depakine chrono [Valproic acid and more 1Valproate sodium] Analogs |
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Interactions Carbamazepine with Depakine chrono
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Dangerous interactions
Clinical manifestations of carbamazepine toxicity have been reported; valproic acid may potentiate the toxic effects of carbamazepine. -
Negative interactions
Careful clinical monitoring of such patients is recommended, especially at the beginning of combination therapy with appropriate dose adjustment of carbamazepine if necessary. Antiepileptic drugs capable of inducing microsomal liver enzymes (including phenytoin, primidone, phenobarbital, carbamazepine) reduce plasma concentrations of valproic acid. Reduces the effects of anticoagulants, anticonvulsants (derivatives of hydantoin or succinimides), barbiturates, clonazepam, primidone, valproic acid. Carbamazepine and Valproic acid belong to the same pharmaceutical group: Normotimics. Carbamazepine and Valproate sodium belong to the same pharmaceutical group: Normotimics. -
Positive interactions
With the simultaneous use of valproic acid and carbamazepine, it is possible to increase the plasma concentration of the active metabolite carbamazepine with signs of overdose. Alternative anticonvulsants may be recommended for patients receiving voriconazole or itraconazole;. - antiepileptic drugs: felbamate, mezuximide, oxcarbazepine, phenobarbital, fensuximide, phenytoin (in order to avoid phenytoin intoxication and the occurrence of subtherapeutic concentrations of carbamazepine, the recommended plasma concentration of phenytoin should be no more than 13 mcg / ml before adding carbamazepine to therapy) and phosphenytoin, primidone, and, although the data are partially contradictory, it is possible. - antifungal agents: itraconazole, voriconazole, alternative anticonvulsants may be recommended for patients receiving voriconazole or itraconazole;. -
Unclear interactions
Carbamazepine. Ethanol and other potentially hepatotoxic drugs. - antiepileptic drugs: styripentol, vigabatrin;. - antiepileptic drugs: clobazam, clonazepam, ethosuximide, felbamate, lamotrigine, eslicarbazepine, oxcarbazepine, primidone, thiagabine, topiramate, valproic acid, zonisamide.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine