Compatibility «Lydase-M» and «Везантра»
Between «Lydase-M» and «Везантра» found 6 negative and 1 positive interaction, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Везантра |
✘Lydase-M [Hyaluronidase] Analogs | |
✘Везантра [Levonorgestrel+Ethinylestradiol and more 2Levonorgestrel, Ethinylestradiol] Analogs |
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Interactions Lydase-M with Везантра
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Negative interactions
The combination of levonorgestrel + ethinyl estradiol may interact with drugs that induce microsomal enzymes, as a result of which the clearance of sex hormones may increase, which in turn may lead to breakthrough uterine bleeding and / or a decrease in the contraceptive effect. Drugs that increase the clearance of levonorgestrel + ethinyl estradiol combination components (weakening the effectiveness by inducing enzymes): phenytoin, barbiturates, primidone, carbamazepine, rifampicin and, possibly. Drugs that reduce the clearance of levonorgestrel + ethinyl estradiol combination components (enzyme inhibitors): strong and moderate CYP3A4 inhibitors, such as azole antifungal drugs (e.g. itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g. clarithromycin, erythromycin), diltiazem and grapefruit juice, can increase plasma concentrations of estrogen or progestin, or both components. It is possible to interact with drugs that induce or inhibit microsomal liver enzymes, as a result of which the clearance of sex hormones may increase or decrease. When using Biogil in patients receiving salicylates, cortisone, ACTH, estrogen or antihistamines in high doses, the effectiveness of the hyaluronidase enzyme may be reduced. - active substances that inhibit the activity of microsomal liver enzymes, such as antifungal agents that are imidazole derivatives (e.g. fluconazole), indinavir or troleandomycin. -
No interactions
If the use of a drug that is an inducer of microsomal liver enzymes is planned to continue, the use of a combination of levonorgestrel + ethinyl estradiol should be carried out without the usual interruption in intake. -
Positive interactions
Women who receive treatment with drugs that are inducers of microsomal enzymes, in addition to the combination of levonorgestrel + ethinyl estradiol, are recommended to temporarily use a barrier method of contraception or choose a non-hormonal method of contraception. -
Unclear interactions
Substances that reduce the clearance of levonorgestrel (enzyme inhibitors), for example:. - substances that induce microsomal liver enzymes, such as rifampicin, rifabutin, barbiturates, anticonvulsants (e.g. carbamazepine, phenytoin or topiramate), griseofulvin, roxaclon, primidone, modafinil, some protease inhibitors (e.g. ritonavir) and St. John's wort preparations;.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine