Compatibility «Metypred» and «Viekira Pak»
Between «Metypred» and «Viekira Pak» found 3 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Viekira Pak |
✘Metypred [Methylprednisolone] Analogs | |
✘Viekira Pak [Dasabuvir; Ombitasvir+Paritaprevir+Ritonavir and more 1Ritonavir] Analogs |
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Interactions Metypred with Viekira Pak
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Negative interactions
GCS can induce the metabolism of HIV protease inhibitors and cause a decrease in their concentration in blood plasma. The combined use of ritonavir and GCS, the exposure of which is significantly increased by the action of strong CYP3A inhibitors, may increase the risk of developing Cushing's syndrome and adrenal suppression. Alternative corticosteroids, including beclomethasone and prednisolone, should be considered, the pharmacokinetics and/or pharmacodynamics of which are less affected by strong CYP3A inhibitors than other studied corticosteroids, especially with prolonged use. -
Unclear interactions
Antiviral drugs (HIV protease inhibitors). HIV protease inhibitors such as indinavir and ritonavir may increase the concentration of GCS in blood plasma. Systemic/inhalation/nasal/ophthalmic GCS, for example betamethasone, budesonide, cyclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, prednisone, triamcinolone. ↑ГКС.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine