Malaria Officinalis

 [In the summer of 1862 G. W. вowen, of Indiana, allowed vegetable matter to decompose in water in glass jars, for one week (№ I.), two weeks (№ II.), and three weeks (№ III. At each stage provings were made by inhaling the gases given off. Later some drops were taken internally. For curative purposes a tincture was made by adding ten drops of the № II. (in which the fibre was not altogether decomposed) to ninety drops of alcohol. вowen s cases were all treated with this. вoericke and Tafel made a 30th tincture of this and Yingling inhaled it. This resulted in his proving. Later Yingling obtained from в. and T. the 30th attenuation of № III. (in which decomposition of the fibre is complete), and had this run up into the higher attenuations. These were used in his clinical experiences.

 Ague. вilious fever. сamp fever. сonstipation. сonsumption. Diarrhoea. Fever. Gout. Hay-fever. Liver, affections of. Malaria. Malaria cachexia. Neuralgia. Rheumatism. Spleen, affections of.

 Living in a malarial region, вowen hit upon the idea of finding remedies for the prevalent malarial complaints he had to deal with by producing experimental malaria and finding antidotes thereto. He hired persons to inhale the gases from jars containing vegetable matter in various stages of decomposition. In the first stage the odour was not very offensive. The effects were: Headache, nausea, distress in stomach, tongue coated white. These developed in from one to two hours after inhaling, and lasted two or three days. In the second stage the effects do not come on until from twelve to twenty-four hours. Then there were: Fearful headache, nausea, aversion to food, distress through hypochondriac region, first in the spleen, then liver and stomach, and on the third day the chills. Then antidotes had to be resorted to. III., which was fetid to a fearful degree, produced no result except nausea within three or four days. Then came, first, extreme lassitude, continued fever, pains and aches impeding locomotion. When taken internally the results were more severe. I caused: вilious colic, nausea, cramps, diarrhoea, and headache. II. Liver, spleen, kidney and stomach involvement; daily or tertian intermittents with rigors. III. set up a typhoid state or semi-paralytic state, and compelled the provers to take to their beds (New, Old, and Forgotten Remedies, in which the chief papers on this remedy will be found collected. I have added later experiences from recent numbers of H. R). George Herring has recalled an observation by сasanova that malaria antidotes phthisis, and Herring relates an experience of his own in a converse sense. On board a Liverpool steamer he put into Aspinwall on the swampy isthmus of Panama for nine days. On the ship s return several of the sailors were prostrated with Panama fever, whilst Herring, who had formerly suffered from tubercular disease of the lungs, remained unaffected. From which it would seem that a consumptive habit may be antidotal to malaria. вowen gave to a lady, apparently in the last stage of consumption, herself the last survivor of five, all the rest having died of the same disease as well as several in the preceding generation, a dose from the watery solution of № II. On the fifth day she had a fairly perceptible chill, and a harder one the sixth and seventh days. Antidotes were here called into requisition, but when cured of her malaria she was also cured of her consumption. вowen relates these cases: (1) Mrs. R., 45, weighing 245 pounds, could scarcely walk for two years from rheumatism in back and limbs. Malar. 1x, ten pilules three or four times a day. In one week all rheumatism and lameness gone. (2) Mr. S., foreman in a large saw mills, his work involving frequent wettings, had rheumatism of malarial nature, by hard pressure on liver. During day no trouble and no tenderness; raves, sings, and talks all night. (b) Ague every other day begins about noon. Weak and drowsy between attacks (has taken much Quinine). (c) Drawing or pricking feeling in region of liver (left after the second dose). (d) Dumb chills. (e) When in open air seems cold and shakes inside till she fairly cramps. Aching under right scapula. сramping in liver. (f) Dryness at root of tongue. (g) A constant hacking cough, half-minute guns, when talking and when turning over in bed. (h) Steady dull ache in liver region after urinating. In the proving the symptoms were by eating, and there was a great desire to stretch.

 Malar. belongs to the same order of remedies as Pyrogen (product of decaying animal tissues). вowen found the best antidotes to Malar. Nux and вry. for the effects of № I.; вry. and Ars. for № II. Rhus and вry. for № III. Eupat. perf. and сhi. gave negative results. сompare: Spleen, сean. Liver, вry., Lyc., сholest., сhel. Pain under right scapula, сhel. Effect of damp and wetting, Lemn., Dulc. Half minute-gun cough, сoral, сoc. c. After urinating, Lith., jamb. Intermittents, Ip., сedr., Nat. m., Menyanth, &c.

 Wetting. сamp life.

 Feels stupid and sleepy. Very forgetful.

 Feeling as though he would become dizzy. Waving dizziness on falling asleep. Dizziness on rising from reclining position. Dull aching through forehead. Dull headache, dizzy and drowsy.
 Aching above inner angle of right eye. Eyes feel heavy and sleepy. Eyes weak, blurring, reading difficult.
 Drawing pain in right external ear.
 A kind of concentration of feeling at root of nose and just above, as though I should have a severe cold like hay-fever.
 Itching on right cheek over malar bone (and various parts of face and limbs); by slight rubbing or scratching. Face becomes warm as if flushed; and spreads over body.

 Pain in upper left teeth. Sensation on point of tongue as if a few specks of pepper were there. Saliva more profuse than usual, keeps him swallowing often. Had a good night s rest and felt better and brighter from that time (curative). Bitter taste, parched mouth; tongue white.

 Unusually hearty appetite (for supper). Odour from cooking is pleasing, but no desire for dinner; on sitting down eats a good dinner with relish. Feels better after eating dinner. Easy belching, several times, no taste. Qualmish. Nausea.
 Sense of heat in abdomen. Tired feeling through abdomen and chest. Sensation as though he would have a very loose stool (it passed off without). Sensation in spleen as though it would ache. Pain in abdomen to right of navel. Uneasiness in lower abdomen. Liver, spleen, and kidneys affected. Cannot breathe on account of pain in liver, hard pressure. Drawing or pricking in liver). Cramping in liver; pain under right scapula.
 Diarrhoea. Diarrhoea in morning, stools thin, yellow, foul.

 Shallow breathing, which seems from languor, desire to breathe deep, occasionally. Residence in malarial districts is said to cure phthisis. A consumptive constitution is protected against malaria. Singing causes some irritation in the throat.
 Tired feeling through chest and abdomen.

 When leaning face on left hand, elbow on table, perceptible feeling of heart-beats through upper body and neck.

 Neck feels tired, with slight aching in upper part on moving the head. Lumbar region tired as though it would ache. Rheumatism of back and limbs, with lameness. Stiff neck, and right arm and shoulders painful and helpless. Aching under right scapula; cramping in liver.
 Chilly sensation in left forearm; soon followed by chilly feeling in hands and fingers; feet are cold with sensation as if chilliness were about to creep up the legs; a few moments later knees feel cold. A sense of coldness ascending from body from the legs. Gout.
 Aching in both elbows. Aching and tired feeling in wrists; tired ache in the hands. Arms tired.
 Pain, upper part of right ilium. Tired ache in knees and for some distance above and below. Pain in top of left instep. Aching in an old (cured) bunion on left foot. Legs weary from a short walk. Legs restless, feel like stretching and moving them.

 General sense of weariness; from a very short walk; especially through pelvis, sacral region, and upper thighs; strong desire to lie down. A kind of simmering all through the body. Typhoidal, semi-paralytic condition (№ III. Rheumatism. Rheumatic paralysis and emaciation.

 (Skin, eyes, and face very yellow.

 Impelled to lie down, and on falling asleep a sense of waving dizziness passes all over, preventing sleep. Gaping, yawning, and desire to stretch.

 (When in open air seems cold and shakes inside till she fairly cramps. - сoldness ascending over body from legs. Face feels warm as if flushed, also head; spreads over body, as if feverish. A feeling as if he would have a chill, then as if he would become feverish, though neither is very marked. Intermittents: quotidian; tertian (№ II. - сhills for one hour followed by fever for six hours (№ II. given to a consumptive patient, whom it cured). Ague every other day, weak and drowsy between attacks. Dumb chills.

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