Compatibility «Ixabepilone» and «Dexamethasone»

• Interactions Ixabepilone with Dexamethasone

  • Dangerous interactions
    • ⓘ Therefore, caution should be exercised when taking them together with the drug Ixempra, as well as, if possible, prescribe alternative drugs that are not inhibitors of the CYP3A4 isoenzyme.
  • Negative interactions
    • ⓘ When prescribing the drug Ixempra with powerful inhibitors of the CYP3A4 isoenzyme (for example, ketoconazole, itraconazole, ritonavir, amprenavir, indinavir, nelfinavir, delavirdine, voriconazole) its dose should be reduced.
    • ⓘ Pharmacokinetic studies have shown that if it is necessary to prescribe the drug Ixempra with powerful inhibitors of the CYP3A4 isoenzyme, the dose of ixabepilon should be reduced to 20 mg/ m2, which will allow maintaining the AUC values of ixabepilon within the limits observed when prescribing ixabepilon without concomitant therapy with CYP3A4 inhibitors.
    • ⓘ When co-therapy with inhibitors of the CYP3A4 isoenzyme and the drug Ixempra, the development of acute toxic reactions should be more carefully monitored (for example, regular monitoring of the blood formula in between courses of treatment).
    • ⓘ Drugs that induce the CYP3A4 isoenzyme (for example, dexamethasone, phenytoin, carbamazepine, rifabutin, rifampicin, phenobarbital, St. John's wort preparations) can accelerate the metabolism of ixabepilon and thereby reduce its concentration in blood plasma to subtherapeutic values.
    • ⓘ Based on the results of a study of the drug interaction of ixabepilon and rifampicin, the following recommendations can be proposed for prescribing ixabepilon to patients who also need concomitant therapy with drugs with a powerful potential for CYP3A4 induction: the dose of ixabepilon can be gradually increased from 40 to 60 mg/ m2, depending on the tolerability of the drug.
    • ⓘ Administration of ixabepilon at a dose of 60 mg/m2 for 4 hours will allow maintaining the AUC values of ixabepilon within the limits observed when prescribing ixabepilon without concomitant therapy with CYP3A4 inducers.
    • ⓘ However, there is no clinical data on the use of an increased dose of ixabepilon in combination with drugs with a powerful potential for CYP3A4 induction, according to this recommendation.
    • ⓘ If concomitant therapy with CYP3A4 inducers is discontinued, the dose of ixabepilon should be reduced to the standard dose.
    • ⓘ Ixabepilon is a CYP3A4 substrate, and concomitant use with dexamethasone, which is an inducer of CYP3A4, may lead to a decrease in ixabepilon concentration to subtherapeutic.
  • Unclear interactions
    • ⓘ Ixabepilon.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine