Compatibility «Dabigatran etexilate» and «Amiodarone»

• Interactions Dabigatran etexilate with Amiodarone

  • Dangerous interactions
    • ⓘ It is recommended to monitor patients using amiodarone and dabigatran etexilate simultaneously with regard to the risk of bleeding, especially in the presence of renal insufficiency (mild to moderate).
    • ⓘ Caution should be exercised when using amiodarone and dabigatran simultaneously due to the risk of bleeding.
  • Negative interactions
    • ⓘ Simultaneous use of P-gp inhibitors (amiodarone, verapamil, quinidine, ketoconazole for systemic use, dronedarone, ticagrelor and clarithromycin) leads to an increase in the concentration of dabigatran in blood plasma.
    • ⓘ Caution should be exercised when concomitantly prescribed with P-gp inhibitors (e.g. amiodarone, quinidine, verapamil and ticagrelor).
    • ⓘ It may be necessary to adjust the dose of dabigatran in accordance with the instructions in its instructions for use.
  • No interactions
    • ⓘ In clinical studies in healthy volunteers, no interactions of dabigatran with atorvastatin (CYP3A4 substrate) and diclofenac (CYP2C9 substrate) were detected.
  • Unclear interactions
    • ⓘ Amiodaronum.
    • ⓘ With the simultaneous use of dabigatran etexilate with a single dose of amiodarone (600 mg) taken orally, the degree and rate of absorption of amiodarone and its active metabolite, desethylamiodarone, did not change.
    • ⓘ Dabigatran.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine