Compatibility «Drospirenone+Ethinylestradiol» and «Etoricoxib»

• Interactions Drospirenone+Ethinylestradiol with Etoricoxib

  • Dangerous interactions
    • ⓘ This increase in the concentration of estrogens should be taken into account when choosing postmenopausal hormone therapy when used in combination with etoricoxib, since increased exposure to estrogens may increase the risk of adverse reactions associated with HRT.
  • Negative interactions
    • ⓘ Increased exposure to ethinyl estradiol may increase the frequency of adverse reactions associated with oral contraceptives (for example, venous thromboembolic events in women at risk).
    • ⓘ The effect of etoricoxib at a dose of 120 mg on the AUC_0-24 of these estrogenic components of premarin was more than 2 times less than that observed when taking premarin alone and increasing the dose from 0.625 to 1.25 mg.
    • ⓘ Etoricoxib is an inhibitor of the activity of human sulfotransferases, in particular SULT1E1, and has been shown to increase the concentration of ethinyl estradiol in blood serum.
  • Positive interactions
    • ⓘ This increase in the concentration of ethinyl estradiol should be taken into account when choosing an oral contraceptive for combined use with etoricoxib.
  • Unclear interactions
    • ⓘ It is worth noting that the irregular or prolonged use of NSAIDs during clinical trials of the combination of drospirenone + ethinyl estradiol was not limited.
    • ⓘ Oral contraceptives.
    • ⓘ Simultaneous use of etoricoxib at a dose of 60 mg and an oral contraceptive (35 mcg ethinyl estradiol and 0.5-1 mg norethindrone) for 21 days increased the AUC_0-24 ethinyl estradiol by 37%.
    • ⓘ Etoricoxib at a dose of 120 mg, taken with the same oral contraceptive simultaneously or with a difference of 12 hours, increased the AUC_0-24 ethinyl estradiol by 50-60%.
    • ⓘ Simultaneous use of etoricoxib for 28 days at a dose of 120 mg and HRT consisting of conjugated estrogens (0.625 mg premarin) increased the mean equilibrium AUC_0-24 of unconjugated estrone (41%), equilin (76%) and 17-β-estradiol (22%).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine