Compatibility «Ciclosporin» and «Desogestrel+Ethinylestradiol»

• Interactions Ciclosporin with Desogestrel+Ethinylestradiol

  • Dangerous interactions
    • ⓘ Cyclosporine (L04AD01) + Hormonal contraceptives (G03A) => The plasma concentration of cyclosporine increases. (A dangerous combination, it should be avoided if possible; plasma concentration control, dose adjustment are needed).
  • Negative interactions
    • ⓘ Chloroquine, a number of macrolide antibiotics (e.g. erythromycin, azithromycin and clarithromycin), antifungal drugs (including ketoconazole and, to a lesser extent, fluconazole, itraconazole, voriconazole), diltiazem, nicardipine, verapamil, metoclopramide, oral contraceptives, danazol, methylprednisolone (high doses), allopurinol, amiodarone; cholic acid and its derivatives, HIV protease inhibitors, imatinib, colchicine; nefazodone.
    • ⓘ COCs can affect the metabolism of other drugs and, accordingly, change their concentrations in blood plasma and in tissues: increase (for example, cyclosporine) or reduce it (lamotrigine, salicylic acid, morphine).
    • ⓘ Accordingly, the concentrations of drugs in plasma and tissues can both increase (for example, cyclosporine) and decrease (for example, lamotrigine).
    • ⓘ - suppress the activity of hepatic microsomal enzymes and, accordingly, increase the concentration in the blood serum of active substances such as diazepam (and other benzodiazepines, whose metabolism is carried out through hydroxylation), cyclosporine, theophylline and prednisolone;.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine