Compatibility «Lercanidipine» and «Amlodipine+Olmasartan medoxomil»

• Interactions Lercanidipine with Amlodipine+Olmasartan medoxomil

  • Dangerous interactions
    • ⓘ In animal studies, after taking BCC (verapamil) and intravenous administration of dantrolene (a drug for the treatment of malignant hyperthermia), cases of ventricular fibrillation and the development of fatal cardiovascular insufficiency were noted against the background of hyperkalemia.
  • Negative interactions
    • ⓘ Due to the risk of hyperkalemia in patients prone to malignant hyperthermia, as well as against the background of the use of dantrolene in malignant hyperthermia, it is recommended to avoid the use of BCC, such as amlodipine.
    • ⓘ Despite the fact that when using amlodipine, there is usually no negative inotropic effect, some BCCs may increase the severity of the negative inotropic effect of antiarrhythmic drugs that cause prolongation of the QT interval (for example, amiodarone, quinidine).
    • ⓘ Amlodipine and Lercanidipine belong to the same pharmaceutical group: Calcium Channel Blockers.
    • ⓘ Amlodipine and Lercanidipine belong to the same pharmaceutical group: Dihydropyridine derivatives.
  • Positive interactions
    • ⓘ Antiviral agents (e.g. ritonavir) increase plasma concentrations of BCC, in pm amlodipine.
    • ⓘ Neuroleptics and isoflurane enhance the antihypertensive effect of BCC derivatives of dihydropyridine.
  • Unclear interactions
    • ⓘ Calcium supplements can reduce the effect of BCC.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine