Compatibility «Prednisolone» and «Digoxin»

• Interactions Prednisolone with Digoxin

  • Dangerous interactions
    • ⓘ With the simultaneous use of prednisolone and cardiac glycosides, the risk of cardiac arrhythmias increases due to the resulting hypokalemia.
    • ⓘ Methylprednisolone (H02AB04) + Digitalis glycosides (C01AA) => Dangerous decrease in potassium levels. It is possible to increase the toxicity of digitalis.
    • ⓘ glucocorticoids, saluretics and other drugs that promote potassium loss, calcium preparations - glycoside intoxication.
    • ⓘ Cardiac glycosides + Amphotericin B, diuretics-benzothiodiazines (dichlothiazide, cyclomethiazide, etc.), glucocorticoids and other drugs that cause hypokalemia, deoxycorticosterone acetate, corticotropin => Cardiac arrhythmia, increased toxic effects of cardiac glycosides.
  • Negative interactions
    • ⓘ cardiac glycosides - their tolerability worsens and the likelihood of ventricular extrasystole increases (due to hypokalemia);.
    • ⓘ Glucocorticoids (H02AB), mineralocorticoids (H02AA) + Diuretics that enhance the excretion of potassium ions (dichlothiazide, etc.), cardiac glycosides, amphotericin B => Hypokalemia syndrome; cardiac arrhythmia, muscle weakness, etc.
    • ⓘ Drugs that cause hypokalemia or intracellular potassium deficiency may cause hypersensitivity to digoxin; these include lithium salts, corticosteroids, carbenoxolone and some diuretics.
  • Positive interactions
    • ⓘ Prednisone H02AB06 + Digitalis glycosides (C01AA) => Dangerous decrease in potassium levels. The toxicity of digitalis glycosides is possible.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine