Compatibility «Ibuprofen+Paracetamol» and «Paracetamol»

• Interactions Ibuprofen+Paracetamol with Paracetamol

  • Dangerous interactions
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Prolonged co-use of paracetamol and other NSAIDs increases the risk of analgesic nephropathy and renal failure.
  • Negative interactions
    • ⓘ Paracetamol already included in the drug: Ibuprofen+Paracetamol..
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Concomitant use with other NSAIDs, in particular selective COX-2 inhibitors, should be avoided due to the possible additive effect (see 'Special instructions').
    • ⓘ As with the use of other drugs containing NSAIDs, the simultaneous use of ibuprofen and acetylsalicylic acid is not recommended due to a possible increase in the likelihood of undesirable effects.
    • ⓘ Ibuprofen and Paracetamol belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
  • Unclear interactions
    • ⓘ Ibuprofen+Paracetamol + Paracetamol analgin and citramon are used together in 18 preparations.
    • ⓘ Ibuprofen + Paracetamol analgin and citramon are used together in 18 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine