Compatibility «Acetylsalicylic acid» and «Diclofenac»

• Interactions Acetylsalicylic acid with Diclofenac

  • Dangerous interactions
    • ⓘ The simultaneous use of diclofenac and analgesic doses of acetylsalicylic acid is usually not recommended due to the increased risk of bleeding.
    • ⓘ Diclofenac, like other NSAIDs, can affect the synthesis of renal PH and increase the toxicity of some drugs.
    • ⓘ The simultaneous use of diclofenac with other NSAIDs or salicylates (for example, diflunizal, salsalate) increases the risk of toxic effects on the gastrointestinal tract with little or no increase in effectiveness.
    • ⓘ Concomitant use of diclofenac with other NSAIDs or salicylates is not recommended.
  • Negative interactions
    • ⓘ Acetylsalicylic acid and Diclofenac belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ The plasma concentration decreases with the use of acetylsalicylic acid.
    • ⓘ Controlled clinical studies have shown that the simultaneous use of NSAIDs and analgesic doses of acetylsalicylic acid does not give a greater therapeutic effect than the use of NSAIDs alone.
    • ⓘ In one clinical study, the simultaneous use of NSAIDs and acetylsalicylic acid was associated with a significant increase in the incidence of adverse reactions from the gastrointestinal tract compared with the use of NSAIDs alone.
    • ⓘ Diclofenac is not a substitute for acetylsalicylic acid, which is used in low doses to protect the CCC.
    • ⓘ With simultaneous use of diclofenac with acetylsalicylic acid, its binding to plasma proteins decreases, although the clearance of free NSAIDs does not change.
    • ⓘ The clinical significance of this interaction is unknown, however, as with other NSAIDs, concomitant administration of diclofenac and acetylsalicylic acid is usually not recommended due to the possibility of increased side effects.
  • Unclear interactions
    • ⓘ Patients taking diclofenac and anticoagulants (e.g., warfarin), antiplatelet agents (e.g., acetylsalicylic acid), SSRIs and SSRIs should be monitored for signs of bleeding.
    • ⓘ Acetylsalicylic acid.
    • ⓘ Other NSAIDs and salicylates.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine