Compatibility «Acetylsalicylic acid» and «Dabigatran etexilate»

• Interactions Acetylsalicylic acid with Dabigatran etexilate

  • Dangerous interactions
    • ⓘ The combined use of dabigatran etexilate with drugs that affect hemostasis or the coagulation system, including unfractionated heparin, low molecular weight heparin, ASA, NSAIDs, vitamin K antagonists, can significantly increase the risk of bleeding.
    • ⓘ The effect of simultaneous administration of dabigatran etexilate and ASA on the risk of bleeding was studied in patients with atrial fibrillation in a randomized phase II trial of combined administration with ASA.
    • ⓘ When studying the simultaneous use of dabigatran etexilate at a dose of 150 mg 2 times a day and ASA in patients with atrial fibrillation, it was found that the risk of bleeding can increase from 12 to 18% (when using ASA at a dose of 81 mg) and up to 24% (when using ASA at a dose of 325 mg).
    • ⓘ NSAIDs used for short-term analgesia after surgery did not increase the risk of bleeding when used concomitantly with dabigatran etexilate.
    • ⓘ Long-term use of NSAIDs increased the risk of bleeding by about 50% both with the combined use of dabigatran etexilate and warfarin.
    • ⓘ Careful monitoring of signs of bleeding is necessary due to the risk of development when combined with NSAIDs (T_1/2 more than 12 hours).
  • Unclear interactions
    • ⓘ Anticoagulants (e.g. coumarin, heparin, warfarin), antiplatelet agents (e.g. clopidogrel and dipyridamole) and SSRIs (e.g. setralin or paroxetine).
    • ⓘ Simultaneous use with antiplatelet agents.
    • ⓘ НПВС.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine