Compatibility «Acetylsalicylic acid+Magnesium hydroxide» and «Hydrochlorothiazide»

• Interactions Acetylsalicylic acid+Magnesium hydroxide with Hydrochlorothiazide

  • Dangerous interactions
    • ⓘ It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension.
    • ⓘ Hydrochlorothiazide may enhance the toxic effect of high doses of salicylates on the central nervous system.
    • ⓘ Amphotericin B (with intravenous administration), gluco - and mineralocorticosteroids (with systemic use), tetracosactide (ACTH), glycyrrhizic acid (carbenoxolone, preparations containing licorice root), laxatives that stimulate intestinal motility.
  • Negative interactions
    • ⓘ Acetylsalicylic acid weakens the effect of uricosuric drugs - benzbromarone, probenicide (reduction of uricosuric effect due to competitive suppression of renal tubular excretion of uric acid), ACE inhibitors (there is a dose-dependent decrease in GFR as a result of inhibition of PG having a vasodilating effect, and, accordingly, a weakening of the hypotensive effect), diuretics (when combined with acetylsalicylic acid in high doses there is a decrease in GFR as a result of a decrease in the synthesis of PG in the kidneys).
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
    • ⓘ NSAIDs can reduce the diuretic and antihypertensive effects of hydrochlorothiazide.
    • ⓘ Against the background of hydrochlorothiazide therapy, it is recommended to use laxatives that do not stimulate intestinal motility.
    • ⓘ Diuretics, Diacarb, dichlotiazide, furosemide, ethacric acid + Amphotericin B, glucocorticoids, corticotropin, cardiac glycosides, laxatives and other agents that promote the excretion of potassium from the body => Cardiac dysfunction, muscle weakness and other manifestations of hypokalemia.
  • Positive interactions
    • ⓘ Diuretics in combination with acetylsalicylic acid in higher doses.
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase-2 (COX-2) inhibitors and high doses of acetylsalicylic acid (≥3 g/day).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine