Compatibility «Indapamide» and «Amlodipine+Telmisartan»

• Interactions Indapamide with Amlodipine+Telmisartan

  • Dangerous interactions
    • ⓘ In elderly patients, patients with reduced BCC (in pm who are on diuretic therapy) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with APA II, including telmisartan, may lead to deterioration of renal function, possibly the development of acute renal failure.
    • ⓘ Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use).
    • ⓘ Previous therapy with high-dose diuretics, including furosemide (a 'loop' diuretic), may lead to a decrease in BCC and an increased risk of arterial hypotension at the beginning of telmisartan therapy.
  • Negative interactions
    • ⓘ Other antihypertensive agents.
    • ⓘ With the simultaneous use of NSAIDs and antihypertensive drugs like telmisartan, a decrease in the antihypertensive effect has been reported by inhibiting the vasodilating effect of PG.
    • ⓘ The safety of the combined use of amlodipine with thiazide diuretics, beta-blockers, ACE inhibitors, long-acting nitrates, nitroglycerin (used sublingually), NSAIDs, antibiotics and hypoglycemic agents for oral administration has been established.
    • ⓘ Other antihypertensive and antianginal drugs.
    • ⓘ Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors.
    • ⓘ The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs.
    • ⓘ In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy.
    • ⓘ Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted.
    • ⓘ ARA II, such as telmisartan, reduces potassium loss caused by diuretics.
    • ⓘ The effect of telmisartan on lowering blood pressure can be enhanced by simultaneous administration of other antihypertensive medications.
    • ⓘ Based on their pharmacological properties, it can be expected that the following drugs can enhance the antihypertensive effect of all antihypertensive agents, including telmisartan: baclofen, amifostin.
  • Positive interactions
    • ⓘ When used concomitantly with other antihypertensive drugs, the antihypertensive effect of the combination of amlodipine + telmisartan may increase.
    • ⓘ It can be expected that some drugs, such as baclofen and amifostine, due to their pharmacological properties, will enhance the antihypertensive effect of all antihypertensive agents, including the combination of amlodipine + telmisartan.
    • ⓘ It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates.
  • Unclear interactions
    • ⓘ Amlodipine + Indapamide analgin and citramon are used together in 4 preparations.
    • ⓘ 'Loop' and thiazide diuretics.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine