Compatibility «Atenolol+Chlortalidone» and «Acetylsalicylic acid»

• Interactions Atenolol+Chlortalidone with Acetylsalicylic acid

  • Dangerous interactions
    • ⓘ Salicylates and nonsteroidal anti-inflammatory drugs (for example, ibuprofen, indomethacin), estrogens can reduce the hypotensive effect of beta-blockers, and with a high dosage of salicylates, an increase in the toxic effect of salicylates on the central nervous system may be observed.
  • Negative interactions
    • ⓘ The hypotensive effect is weakened by NSAIDs (blockade of PG synthesis and delay of Na⁺) and estrogens (delay of Na⁺).
    • ⓘ NSAIDs, estrogens, sympathomimetics, xanthines weaken the hypotensive effect, absorption, increase - sympatholytics, nitroglycerin, hydralazine and other hypotensive drugs, antacids - slow down absorption.
    • ⓘ NSAIDs (for example, ibuprofen, indomethacin) can reduce the antihypertensive effect of atenolol (by delaying sodium ions and blocking prostaglandin synthesis by the kidneys).
    • ⓘ NSAIDs weaken the diuretic and hypotensive effects.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
  • Positive interactions
    • ⓘ Diuretics in combination with acetylsalicylic acid in higher doses.
  • Unclear interactions
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine