Compatibility «Spironolactone» and «Valsartan+Sacubitril»

• Interactions Spironolactone with Valsartan+Sacubitril

  • Dangerous interactions
    • ⓘ The use of valsartan + sacubitril complex simultaneously with NSAIDs in patients over the age of 65 years, in patients with hypovolemia (including patients receiving diuretics) and patients with impaired renal function may increase the risk of deterioration of renal function.
    • ⓘ Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia.
    • ⓘ The simultaneous use of valsartan with other drugs that block RAAS, potassium-sparing diuretics (for example, spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium, or other drugs that can increase potassium levels (for example, heparin), may lead to an increase in serum potassium, and in patients with heart failure - to increase serum creatinine.
    • ⓘ In elderly patients, patients with dehydration (including those taking diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm valsartan, may lead to deterioration of renal function, including possible acute renal failure.
  • Negative interactions
    • ⓘ The simultaneous use of potassium-sparing diuretics (e.g. triamterene and amiloride), mineralocorticoid antagonists (e.g. spironolactone and eplerenone), potassium preparations or potassium-containing salt substitutes may cause an increase in potassium content and creatinine concentration in blood serum.
    • ⓘ In the case of additional use of diuretic drugs, the risk of toxic effects of lithium may increase.
    • ⓘ Angiotensin II antagonists, aldosterone blockers, heparin, low molecular weight heparin and other drugs that cause hyperkalemia.
    • ⓘ Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine