Compatibility «Nifedipine» and «Bendazol+Metamizole sodium+Papaverine+Phenobarbital»

• Interactions Nifedipine with Bendazol+Metamizole sodium+Papaverine+Phenobarbital

  • Negative interactions
    • ⓘ NSAIDs reduce the antihypertensive effect of nifedipine due to suppression of prostaglandid synthesis, sodium and fluid retention in the body.
    • ⓘ Nifedipine can displace drugs characterized by a high degree of binding from protein binding (in pm indirect anticoagulants - coumarin and indanedione derivatives, anticonvulsants, nonsteroidal anti-inflammatory drugs, quinine, salicylates, sulfinpyrazone), as a result of which their concentration in blood plasma may increase.
    • ⓘ Calcium channel blockers - phenobarbital leads to a decrease in the levels of felodipine, isradipine, diltiazem, verapamil, nimodipine and nifedipine, which may require an increase in their doses;.
  • No interactions
    • ⓘ Clinical studies on the potential interaction of nifedipine and carbamazepine or phenobarbital have not been conducted.
  • Positive interactions
    • ⓘ A combination of the drug with nitrates (including nitroglycerin, isosorbide dinitrate), slow calcium channel blockers (nifedipine, etc.;), beta‑blockers (including propranolol, metoprolol), ganglioblockers (including azamethonium bromide), diuretics (furosemide, hypothyazide, etc.;), vasodilators (in including dipyridamole), aminophyllin enhances the hypotensive effect of the drug Andipal.
  • Unclear interactions
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs).
    • ⓘ Antiepileptic drugs that induce the CYP3A4 isoenzyme (for example, phenytoin, carbamazepine, phenobarbital).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine