Compatibility «Nifedipine» and «Atenolol+Chlortalidone»

• Interactions Nifedipine with Atenolol+Chlortalidone

  • Dangerous interactions
    • ⓘ Concomitant therapy with dihydropyridines, for example, nifedipine, may increase the risk of a marked decrease in blood pressure, in patients with latent heart failure, signs of circulatory disorders may appear.
    • ⓘ With the simultaneous use of nifedipine and beta-blockers, it is necessary to carefully monitor the patient's condition, since in some cases it is possible to aggravate the course of chronic heart failure.
    • ⓘ With the simultaneous use of beta‑blockers with nonhydropyridine BMCC, such as verapamil and diltiazem, the negative effect on myocardial contractility and atrioventricular conduction increases, which can lead to severe arterial hypotension, atrioventricular blockade and cardiac arrest.
    • ⓘ Simultaneous use of atenolol and nifedipine can lead to a significant decrease in blood pressure and the appearance of symptoms of heart failure (in patients with latent heart failure).
    • ⓘ beta-blockers (C07) + Verapamil, reserpine, phenigidine => Increased existing heart failure, bradycardia, impaired conduction.
    • ⓘ Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use).
  • Negative interactions
    • ⓘ The use of beta-blockers in combination with blockers of 'slow' calcium channels that have a negative inotropic effect, for example, verapamil, diltiazem, can lead to an increase in this effect, especially in patients with reduced myocardial contractility and/ or with impaired sinoatrial or atrioventricular conduction.
    • ⓘ The blocker of 'slow' calcium channels should not be used intravenously for 48 hours after the withdrawal of the beta-blocker.
  • Positive interactions
    • ⓘ Nitrates, beta-blockers, diuretics, tricyclic antidepressants, fentanyl, alcohol - enhance the hypotensive effect.
    • ⓘ The antihypertensive effect of nifedipine may be enhanced when used concomitantly with antihypertensive drugs such as diuretics, beta-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARA II), other BMCC, alpha-blockers, phosphodiesterase‑5 inhibitors, methyldopa.
    • ⓘ Enhances the effect of curare-like muscle relaxants and antihypertensive drugs (in pm guanethidine, methyldopa, beta-blockers, vasodilators, BCC, MAO inhibitors).
  • Unclear interactions
    • ⓘ Blockers of 'slow' calcium channels (BMCC).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine