Compatibility «Irbesartan» and «Diclofenac»

• Interactions Irbesartan with Diclofenac

  • Dangerous interactions
    • ⓘ As with ACE inhibitors, the combined use of angiotensin II antagonists and NSAIDs may increase the risk of impaired renal function, including the likelihood of acute renal failure, and lead to an increase in serum potassium levels, especially in patients with already impaired renal function.
    • ⓘ In elderly patients, patients with hypovolemia or with impaired renal function, the use of NSAIDs, including COX-2 inhibitors, simultaneously with ARA II, including irbesartan, may lead to deterioration of renal function, including the possible development of acute renal failure.
    • ⓘ In elderly patients with hypovolemia (in pm receiving diuretics) or renal insufficiency, the combined use of NSAIDs and ACE inhibitors or ARA II may lead to deterioration of renal function, including the possible development of acute renal failure.
    • ⓘ With the simultaneous use of diclofenac and ACE inhibitors or ARA II in elderly patients with hypovolemia or impaired renal function, signs of deterioration in renal function should be monitored.
  • Negative interactions
    • ⓘ NSAIDS: with simultaneous administration of angiotensin II antagonists and NSAIDs (for example, selective COX-2 inhibitors, acetylsalicylic acid > 3 g / day and non-selective NSAIDs), the antihypertensive effect may decrease.
    • ⓘ With the simultaneous use of ARA II and NSAIDs (including selective COX-2 inhibitors), the antihypertensive effect of irbesartan may be weakened.
    • ⓘ Renal function should be regularly monitored in patients taking irbesartan and NSAIDs simultaneously, including selective COX-2 inhibitors.
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine