Compatibility «Neostigmine methylsulfate» and «Suxamethonium iodide»

• Interactions Neostigmine methylsulfate with Suxamethonium iodide

  • Dangerous interactions
    • ⓘ Proserin-Darnitsa and depolarizing muscle relaxants (suxamethonium iodide, etc.) are pharmacologically incompatible, since the effect of suxamethonium iodide increases with direct interaction.
    • ⓘ N-Cholinomimetics; M-Cholinomimetics; M-, n-Cholinomimetics, pm anticholinesterase agents(N06DA,N07AA, A03F, S01EB) + muscle relaxants(M03AB) => Respiratory arrest is possible.
    • ⓘ Anticholinesterase drugs (N07AA) + Depolarizing muscle relaxants => Respiratory arrest is possible.
    • ⓘ Depolarizing muscle relaxants (M03) + Anticholinesterase agents (proserin, galantamine) => Increased muscle relaxation, delayed recovery of voluntary breathing.
  • Negative interactions
    • ⓘ However, in the case of the use of depolarizing muscle relaxants in large doses, an antidepolarizing effect ('double block') develops after the depolarizing effect, therefore it is advisable to prescribe Proserin-Darnitsa.
  • Positive interactions
    • ⓘ Prolongs and enhances (with parenteral administration) the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.;).
    • ⓘ Enhance and prolong the muscle relaxant effect: anticholinesterase agents and drugs with the potential to reduce the activity of blood cholinesterase (aprotinin, diphenhydramine, promethazine, estrogens, oxytocin, glucocorticosteroids in high doses, oral contraceptives), procaine, procainamide, lidocaine, verapamil, beta-blockers, aminoglycosides, amphotericin B, clindamycin, cyclopropane, propanidide, organophosphorus insecticides, magnesium salts and lithium, quinidine, quinine, chloroquine, pancuronium bromide.
  • Unclear interactions
    • ⓘ Reduces the effectiveness of antimiasthenic drugs.
    • ⓘ anticholinesterase drugs, procaine, procainamide, lidocaine, verapamil, beta-blockers, aminoglycoside antibiotics, amphotericin B, clindamycin, cyclopropane, propanidide, organophosphorus insecticides, magnesium sulfate (infusion of magnesium salts should be stopped 20-30 minutes before administration of the drug) and lithium salts, quinidine, quinine, chloroquine, pancuronium , antiarrhythmic drugs Class I, blockers of 'slow' calcium channels, 'loop'.
    • ⓘ Suxamethonium iodide reduces the effectiveness of antimyasthenic drugs.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine