Compatibility «Clarithromycin» and «Drospirenone+Ethinylestradiol»

• Interactions Clarithromycin with Drospirenone+Ethinylestradiol

  • Dangerous interactions
    • ⓘ Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index), reduces the effectiveness of drugs, during the metabolism of which paraaminobenzoic acid is formed, ethinyl estradiol - the risk of 'breakthrough' bleeding.
  • Negative interactions
    • ⓘ In clinical studies, the use of a hormonal contraceptive containing ethinyl estradiol did not lead to an increase or led only to a slight increase in the concentration of CYP3A4 substrates in blood plasma (for example, midazolam), while the concentration of CYP1A2 substrates in blood plasma may increase slightly (for example, theophylline) or moderately (for example, melatonin and tizanidine).
  • No interactions
    • ⓘ In vitro studies, drospirenone did not affect the metabolism of model substrates involving CYP1A2 and CYP2D6, but inhibited the metabolism of CYP1A1, CYP2C9, CYP2C19 and CYP3A4 substrates, with CYP2C19 proving to be the most sensitive enzyme.
    • ⓘ Two additional clinical drug interaction studies using simvastatin and midazolam as marker substrates for CYP3A4 were performed with 24 healthy postmenopausal women.
    • ⓘ The results of these studies demonstrated that the pharmacokinetics of CYP3A4 substrates were not affected by ss'>C_ss drospirenone achieved after its administration at a dose of 3 mg/day.
  • Unclear interactions
    • ⓘ Strong and moderate CYP3A4 inhibitors such as azole antifungal drugs (e.g. ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g. clarithromycin, erythromycin), diltiazem and grapefruit juice may increase the concentration of estrogen or progestin, or both components, in blood plasma.
    • ⓘ The potential effect of drospirenone on the activity of CYP2C19 and CYP3A4 has been studied in clinical pharmacokinetic studies using omeprazole, simvastatin and midazolam as marker substrates.
    • ⓘ In vitro, ethinyl estradiol is a reversible inhibitor of CYP2C19, CYP1A1 and CYP1A2, as well as, by mechanism of action, an inhibitor of CYP3A4/5, CYP2C8 and CYP2J2.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine