Compatibility «Lisinopril» and «Amlodipine+Indapamide»

• Interactions Lisinopril with Amlodipine+Indapamide

  • Dangerous interactions
    • ⓘ The risk of sudden hypotension and/or acute renal failure at the beginning of treatment with an ACE inhibitor against the background of an already existing decrease in sodium levels (especially in patients with renal artery stenosis).
    • ⓘ In CHF, treatment with ACE inhibitors should begin with low doses with a possible preliminary reduction in doses of diuretics.
    • ⓘ Starting lisinopril in patients taking diuretics may lead to an excessive decrease in blood pressure.
    • ⓘ In the elderly, patients with reduced BCC (in pm receiving diuretic therapy) or impaired renal function, the co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including lisinopril, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ The administration of ACE inhibitors to patients with hyponatremia (especially patients with renal artery stenosis) is accompanied by a risk of developing sudden arterial hypotension and/or acute renal failure.
    • ⓘ In chronic heart failure, treatment with ACE inhibitors should begin with the lowest doses, with a possible preliminary reduction in doses of diuretics.
  • Negative interactions
    • ⓘ - 3 days before the start of treatment with an ACE inhibitor, stop taking diuretics.
    • ⓘ - or prescribe an ACE inhibitor at a low initial dose and gradually increase the dose.
    • ⓘ When used simultaneously with vasodilators, beta-blockers, BMCC, diuretics and other antihypertensive drugs, the severity of the antihypertensive effect of lisinopril increases.
    • ⓘ Other antihypertensive and antianginal drugs.
    • ⓘ Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors.
    • ⓘ The possibility of hypotensive effects when taking lisinopril can be minimized by reducing or stopping the diuretic or increasing salt intake before starting treatment with lisinopril.
    • ⓘ Lisinopril attenuates potassium loss caused by thiazide-type diuretics.
    • ⓘ Other antihypertensive drugs.
    • ⓘ Blood pressure should be carefully monitored and, if necessary, the dose of antihypertensive drugs should be adjusted.
    • ⓘ The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs.
    • ⓘ In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy.
    • ⓘ 3 days before the start of treatment with an ACE inhibitor, stop taking diuretics; in the future, if necessary, taking a non-potassium-sparing diuretic can be resumed;.
    • ⓘ if discontinuation of diuretics is not possible, then ACE inhibitor therapy should be started at low doses, followed by a gradual increase in the dose if necessary.
    • ⓘ In all cases, in the first week of taking ACE inhibitors in patients, it is necessary to monitor renal function (creatinine concentration in blood plasma).
    • ⓘ Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted.
  • Positive interactions
    • ⓘ It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates.
  • Unclear interactions
    • ⓘ ACE inhibitors.
    • ⓘ In all cases, renal function (plasma creatinine levels) should be monitored during the first weeks of treatment with an ACE inhibitor.
    • ⓘ Amlodipine + Lisinopril analgin and citramon are used together in 9 preparations.
    • ⓘ Diuretics.
    • ⓘ If it is necessary to continue taking a diuretic, the initial dose of lisinopril should be reduced.
    • ⓘ Lisinopril + Indapamide analgin and citramon are used together in Diroton Plus, Эквапресс.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine