Compatibility «Lisinopril» and «Acetylsalicylic acid+Magnesium hydroxide»

• Interactions Lisinopril with Acetylsalicylic acid+Magnesium hydroxide

  • Dangerous interactions
    • ⓘ In the elderly, patients with reduced BCC (in pm receiving diuretic therapy) or impaired renal function, the co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including lisinopril, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ In some patients with impaired renal function (for example, in elderly patients or patients with dehydration) receiving NSAID therapy (in pm with selective COX-2 inhibitors), the simultaneous use of ACE inhibitors or ARA II may cause further deterioration of renal function, including the development of acute renal failure, and hyperkalemia.
    • ⓘ Concomitant use of ACE inhibitors and NSAIDs should be carried out with caution (especially in elderly patients and in patients with impaired renal function).
    • ⓘ The use of lisinopril in combination with acetylsalicylic acid as an antiplatelet agent is not contraindicated.
  • Negative interactions
    • ⓘ Acetylsalicylic acid weakens the effect of uricosuric drugs - benzbromarone, probenicide (reduction of uricosuric effect due to competitive suppression of renal tubular excretion of uric acid), ACE inhibitors (there is a dose-dependent decrease in GFR as a result of inhibition of PG having a vasodilating effect, and, accordingly, a weakening of the hypotensive effect), diuretics (when combined with acetylsalicylic acid in high doses there is a decrease in GFR as a result of a decrease in the synthesis of PG in the kidneys).
    • ⓘ Periodic monitoring of renal function in patients taking lisinopril and NSAIDs is recommended.
    • ⓘ NSAIDs can reduce the antihypertensive effect of ACE inhibitors, including lisinopril.
    • ⓘ NSAIDs (in pm, selective COX-2 inhibitors) and acetylsalicylic acid in doses > 3 g / day reduce the antihypertensive effect of lisinopril.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
  • Positive interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors and high doses of acetylsalicylic acid (>3 g /day).
    • ⓘ ACE inhibitors in combination with acetylsalicylic acid in higher doses.
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.
    • ⓘ Antacids and colestyramine reduce the absorption of lisinopril in the gastrointestinal tract.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine