Compatibility «Metamizole sodium» and «Amlodipine+Valsartan»

• Interactions Metamizole sodium with Amlodipine+Valsartan

  • Dangerous interactions
    • ⓘ In elderly patients, patients with dehydration (including those taking diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm valsartan, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ If it is necessary to use valsartan and NSAIDs simultaneously, before starting treatment, it is necessary to evaluate kidney function and correct violations of the water-electrolyte balance.
  • Negative interactions
    • ⓘ Renal function should be periodically monitored in patients receiving valsartan and NSAIDs.
    • ⓘ The antihypertensive effect of ARA II, in pm valsartan, can be weakened by NSAIDs, including selective COX-2 inhibitors.
    • ⓘ When used concomitantly with NSAIDs, including selective COX-2 inhibitors and acetylsalicylic acid in high doses (≥ 3 g / day), it is possible to reduce the antihypertensive effect of valsartan.
    • ⓘ When using ARA II simultaneously with NSAIDs, it is possible to worsen kidney function and increase the potassium content in blood plasma.
  • No interactions
    • ⓘ Unlike other BMCC, no clinically significant interaction of amlodipine was found when combined with NSAIDs, in pm with indomethacin.
    • ⓘ Unlike other BMCC, no clinically significant interaction of amlodipine was found when combined with nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin.
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.
    • ⓘ НПВП.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine