Compatibility «Acarbose» and «Glibenclamide+Metformin»

• Interactions Acarbose with Glibenclamide+Metformin

  • Negative interactions
    • ⓘ Associated with the use of all hypoglycemic agents.
    • ⓘ Precautions: the patient should be warned about the need for self-monitoring of blood glucose; if necessary, adjust the dose of a hypoglycemic agent during simultaneous use of a neuroleptic and after discontinuation of its use.
    • ⓘ Precautions: the patient should be warned about the need for self-monitoring of blood glucose; if necessary, the dose of hypoglycemic agent should be adjusted during simultaneous use of GCS and after discontinuation of their use.
    • ⓘ Beta₁-adrenoblockers, clonidine, reserpine, guanethidine and sympatholytics: mask some symptoms of hypoglycemia - palpitations and tachycardia.
    • ⓘ The patient should be warned about the need for self-monitoring of blood glucose; it may be necessary to adjust the dose of hypoglycemic agents during simultaneous treatment with fluconazole and after discontinuation of its use.
    • ⓘ Antibacterial drugs from the sulfonamide group, fluoroquinolones, anticoagulants (coumarin derivatives), MAO inhibitors, chloramphenicol, pentoxifylline, lipid-lowering drugs from the fibrate group, disopyramide: the risk of hypoglycemia against the background of glibenclamide use.
    • ⓘ When such drugs are discontinued in patients receiving acarbose in combination with sulfonylurea derivatives or insulin, patients should be carefully monitored for signs of hypoglycemia.
    • ⓘ The use of acarbose in patients receiving sulfonylurea derivatives or insulin, which can cause hypoglycemia, may lead to a further decrease in blood glucose levels and increase the likelihood of hypoglycemia.
    • ⓘ Very rarely, isolated cases of hypoglycemic shock have been reported in patients treated with acarbose in combination with sulfonylurea derivatives and/or insulin.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine