Compatibility «Streptomycin» and «Ceftriaxone»

• Interactions Streptomycin with Ceftriaxone

  • Dangerous interactions
    • ⓘ However, it is unacceptable to mix streptomycin in one syringe or one infusion system with beta-lactam antibiotics (penicillins, cephalosporins), as well as with heparin due to physico-chemical incompatibility.
    • ⓘ It should not be used simultaneously with viomycin, polymyxin B, methoxyflurane, amphotericin B, ethacric acid, vancomycin, capreomycin and other oto- and nephrotoxic agents, as well as with furosemide.
    • ⓘ Ceftriaxone is pharmacologically incompatible with amsacrine, vancomycin, fluconazole and aminoglycosides.
    • ⓘ Cephalosporins (J01DE) + Aminoglycosides, glycopeptides, loop diuretics and other drugs with nephrotoxic effects => Increased risk of nephrotoxic effects.
  • Negative interactions
    • ⓘ Aminoglycosides (J01G) + Vancomycin, cephalosporins => Increased nephrotoxic effect.
    • ⓘ There are conflicting data on the likelihood of increased nephrotoxicity of aminoglycosides when used with cephalosporins, therefore, it is necessary to monitor renal function and the concentration of aminoglycosides in the blood.
    • ⓘ The synergism between ceftriaxone and aminoglycosides has been shown in relation to many gram-negative bacteria.
    • ⓘ Cephalosporins (J01DB) + Aminoglycosides, furosemide, ethacric acid => Increased nephrotoxic effect.
  • Positive interactions
    • ⓘ When combined with penicillins or cephalosporins, there is synergy with respect to some aerobes.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine