Compatibility «Ibuprofen» and «Indapamide+Ramipril»

• Interactions Ibuprofen with Indapamide+Ramipril

  • Negative interactions
    • ⓘ Concomitant use with NSAIDs, including selective COX-2 inhibitors and acetylsalicylic acid in doses having an anti-inflammatory effect (more than 3 g / day), reduces the antihypertensive effect of indapamide and ramipril.
    • ⓘ Concomitant use with NSAIDs, including selective COX-2 inhibitors and non-selective NSAIDs, for example acetylsalicylic acid in doses having an anti-inflammatory effect (more than 3 g / day), reduces the antihypertensive effect of indapamide and ramipril.
    • ⓘ Antihypertensive drugs, beta-blockers and diuretics.
    • ⓘ NSAIDs can reduce the antihypertensive effect of antihypertensive drugs, in pm ACE inhibitors, angiotensin II receptor antagonists, beta-blockers and diuretics.
    • ⓘ Diuretics may also increase the risk of nephrotoxic effects of NSAIDs.
    • ⓘ Ibuprofen reduces the effect of antihypertensive drugs (in pm BCC and ACE inhibitors), natriuretic and diuretic activity of furosemide and hydrochlorothiazide, and the effectiveness of uricosuric drugs.
    • ⓘ Attenuation of action - estrogens, NSAIDs, sympathomimetics.
  • Positive interactions
    • ⓘ Nonsteroidal anti-inflammatory drugs (with systemic administration), including selective COX-2 inhibitors, high doses of acetylsalicylic acid ≥ 3 g / day).
    • ⓘ When used simultaneously with hypnotics, narcotic and analgesic drugs, it is possible to enhance the antihypertensive effect.
    • ⓘ Nonsteroidal anti-inflammatory drugs (with systemic use), including selective cyclooxygenase-2 (COX-2) inhibitors, and high doses of acetylsalicylic acid (≥ 3 g /day).
  • Unclear interactions
    • ⓘ With NSAIDs (indomethacin, acetylsalicylic acid).
    • ⓘ With sleeping pills, narcotic drugs and painkillers.
    • ⓘ With nonsteroidal anti-inflammatory drugs (indomethacin, acetylsalicylic acid).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine