Compatibility «Atenolol comp» and «Sotalol hydrochloride»

• Interactions Atenolol comp with Sotalol hydrochloride

  • Dangerous interactions
    • ⓘ If both medications are prescribed, the beta-blockers should be discontinued a few days before discontinuation of clonidine.
    • ⓘ Salicylates and nonsteroidal anti-inflammatory drugs (for example, ibuprofen, indomethacin), estrogens can reduce the hypotensive effect of beta-blockers, and with a high dosage of salicylates, an increase in the toxic effect of salicylates on the central nervous system may be observed.
    • ⓘ The anesthesiologist should be informed about the use of Tenonorm and a general anesthetic should be selected that has the least negative inotropic effect, as far as possible, The use of beta-blockers together with drugs for anesthesia can lead to an increased risk of arterial hypotension.
    • ⓘ Antiarrhythmic and anesthetic agents enhance the cardiodepressive effect (the risk of developing bradycardia, arrhythmia, hypotension, heart failure increases).
  • Negative interactions
    • ⓘ Beta-blockers can exacerbate 'rebound' hypertension, which can occur after clonidine withdrawal.
    • ⓘ If it is necessary to replace clonidine with a beta-adrenoblocker, the latter should be prescribed a few days after discontinuation of treatment with clonidine.
    • ⓘ It is necessary to prescribe beta-blockers with caution in combination with Class I antiarrhythmic drugs such as disopyramide (the cardiodepressive effect may be cumulative).
    • ⓘ Concomitant use of sympathomimetic agents, for example, epinephrine, norepinephrine, can neutralize the effect of beta-blockers (a significant increase in blood pressure).
    • ⓘ The use of beta-blockers in combination with blockers of 'slow' calcium channels that have a negative inotropic effect, for example, verapamil, diltiazem, can lead to an increase in this effect, especially in patients with reduced myocardial contractility and/ or with impaired sinoatrial or atrioventricular conduction.
    • ⓘ The blocker of 'slow' calcium channels should not be used intravenously for 48 hours after the withdrawal of the beta-blocker.
    • ⓘ Sotalol and Atenolol belong to the same pharmaceutical group: Beta blockers.
    • ⓘ The use of diuretics of this type can lead to hypokalemia or hypomagnesemia, which increases the likelihood of arrhythmia of the 'pirouette' type.
    • ⓘ Tricyclic antidepressants, barbiturates, phenothiazines, narcotic and antihypertensive drugs, diuretics and vasodilators can cause a sharp decrease in blood pressure.
  • No interactions
    • ⓘ When taken simultaneously with verapamil, diltiazem, digoxin, amiodarone, antiarrhythmics, anesthetics, there is an increase in the severity of negative chrono-, ino- and dromotropic effects.
    • ⓘ Cardiac glycosides in combination with beta-blockers can increase the time of atrioventricular conduction.
  • Positive interactions
    • ⓘ Enhances the effect of curare-like muscle relaxants and antihypertensive drugs (in pm guanethidine, methyldopa, beta-blockers, vasodilators, BCC, MAO inhibitors).
    • ⓘ Hypotension is enhanced by tricyclic antidepressants, barbiturates, phenothiazine derivatives, narcotic analgesics, haloperidol, vasodilators, diuretics.
  • Unclear interactions
    • ⓘ Antiarrhythmic drugs.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,032,480 possible combinations of drugs and their components were found 412,568 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-03-05

Category - medicine