Compatibility «Aciclovir forte» and «Valacyclovir»

• Interactions Aciclovir forte with Valacyclovir

  • Dangerous interactions
    • ⓘ The pharmacokinetics of digoxin did not depend on simultaneous administration of valacyclovir 1 g 3 times a day, and the pharmacokinetics of acyclovir after a single dose of valacyclovir (1 g) did not change with simultaneous administration of digoxin (2 doses of 0.75 mg).
  • Negative interactions
    • ⓘ max'>C_max and AUC of acyclovir after a single dose of valacyclovir (1 g) increased by 8 and 32%, respectively, after a single dose of cimetidine (800 mg).
    • ⓘ max'>C_max and AUC of acyclovir after a single dose of valacyclovir (1 g) increased by 30 and 78%, respectively, after co-administration with a combination of cimetidine and probenecid, primarily due to a decrease in renal clearance of acyclovir.
    • ⓘ max'>C_max and AUC of acyclovir after a single dose of valacyclovir (1 g) increased by 22 and 49%, respectively, after taking probenecid (1 g).
    • ⓘ Valaciclovir and Aciclovir belong to the same pharmaceutical group: Antiviral (with the exception of HIV) drugs.
  • No interactions
    • ⓘ The pharmacokinetics of acyclovir after a single dose of valacyclovir (1 g) did not change with the simultaneous use of several doses of thiazide diuretics.
  • Unclear interactions
    • ⓘ The pharmacokinetics of acyclovir after a single dose of valacyclovir (1 g) remained unchanged with simultaneous administration of a single dose of antacids (Al³⁺ or Mg²⁺).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,041,552 possible combinations of drugs and their components were found 412,577 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-06-18

Category - medicine