Compatibility «Sotahexal» and «Lerkamen»

• Interactions Sotahexal with Lerkamen

  • Dangerous interactions
    • ⓘ Simultaneous administration of beta-blockers and blockers of 'slow' calcium channels can lead to arterial hypotension, bradycardia, impaired conduction and heart failure.
    • ⓘ Calcium channel blockers (C08,C08CA) + Class I and III antiarrhythmic drugs (C01B) => Significantly increases the likelihood of ventricular fibrillation. (The combination should be avoided).
  • Negative interactions
    • ⓘ Cardiac glycosides, reserpine, clonidine, alpha-methyldofa, guanfacine potentiate heart rate reduction and inhibition of intracardiac conduction, calcium antagonists block beta-adrenergic receptors, amiodarone - the risk of arrhythmias.
    • ⓘ Simultaneous use of beta-blockers and blockers of 'slow' calcium channels that suppress myocardial function (for example, verapamil and diltiazem) should be avoided due to the additive effect of these agents on atrioventricular conduction and ventricular function.
    • ⓘ Caution should be exercised when concomitantly prescribing lercanidipine with other CYP3A4 substrates such as terfenadine, astemizole, Class III antiarrhythmic drugs such as amiodarone, sotalol.
    • ⓘ This effect may be associated with a decrease in hepatic blood flow caused by beta-blockers, and may occur when taking other drugs of this class.
  • No interactions
    • ⓘ It is compatible with beta-blockers, diuretics, ACE inhibitors.
    • ⓘ When lercanidipine was co-administered with metoprolol (a beta-adrenoblocker that is mainly biotransformed in the liver), the bioavailability of metoprolol did not change, while the bioavailability of lercanidipine decreased by 50%.
  • Unclear interactions
    • ⓘ Blockers of 'slow' calcium channels.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine