Compatibility «Clarithromycin» and «Alfa Normix»
Between «Clarithromycin» and «Alfa Normix» found 2 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Alfa Normix |
| ✘Clarithromycin [Clarithromycin] Analogs | |
| ✘Alfa Normix [Rifaximin] Analogs |
-
Interactions Clarithromycin with Alfa Normix
-
Negative interactions
- In vitro studies show that rifaximin does not inhibit cytochrome P450 isoenzymes (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4) and does not induce CYP1A2 and CYP2B6, but is a weak inducer of CYP3A4.
- It is unknown whether drugs that inhibit CYP3A4 increase the systemic exposure of rifaximin when used concomitantly with it.
-
No interactions
- A clinical study in healthy volunteers showed that taking rifaximin 200 mg orally every 8 hours for 3 days or every 8 hours for 7 days had no effect on the pharmacokinetics of a single dose of the CYP3A4 substrate midazolam (2 mg IV or 6 mg orally).
- Thus, rifaximin had no significant effect on the intestinal or hepatic activity of CYP3A4.
-
Unclear interactions
- In vitro studies indicate that rifaximin induces the cytochrome P450 CYP3A4 isoenzyme.
- In vitro studies suggest that rifaximin is a moderate substrate of P-gp and is metabolized by the CYP3A4 isoenzyme.
-
Negative interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- Do you need an API for interactions/drug analogues for your project? Write to us.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2026-05-28
Category - medicine