Compatibility «Celebrex» and «Aspirin»

• Interactions Celebrex with Aspirin

  • Dangerous interactions
    • ⓘ The simultaneous use of celecoxib and analgesic doses of acetylsalicylic acid is usually not recommended due to the increased risk of bleeding.
  • Negative interactions
    • ⓘ The condition of patients taking celecoxib simultaneously with anticoagulants (for example, warfarin), antiplatelet drugs (for example, acetylsalicylic acid), SSRIs and SSRIs should be monitored for signs of bleeding.
    • ⓘ Controlled clinical studies have shown that the simultaneous use of NSAIDs and analgesic doses of acetylsalicylic acid does not give a greater therapeutic effect than the use of NSAIDs alone.
    • ⓘ In a clinical study, with the simultaneous use of NSAIDs and acetylsalicylic acid, a significantly higher number of side effects from the gastrointestinal tract were revealed compared with the use of NSAIDs alone.
    • ⓘ With the simultaneous use of NSAIDs and acetylsalicylic acid, the binding of NSAIDs to plasma proteins decreased, although the clearance of free NSAIDs did not change.
    • ⓘ The use of celecoxib is not an alternative to low doses of acetylsalicylic acid to protect the CCC.
    • ⓘ The simultaneous use of celecoxib and other NSAIDs or salicylates (for example, diflunizal, salsalate) increases the risk of toxic damage to the gastrointestinal tract, with virtually no increase in effectiveness.
    • ⓘ Celecoxib and Acetylsalicylic acid belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
  • No interactions
    • ⓘ In two studies in healthy volunteers and in patients with osteoarthritis and confirmed heart disease, respectively, celecoxib (at a dose of 200 to 400 mg / day) demonstrated no effect on the cardioprotective and antiplatelet effects of acetylsalicylic acid (100-325 mg).
  • Unclear interactions
    • ⓘ Acetylsalicylic acid.
    • ⓘ NSAIDs and salicylates.
    • ⓘ Concomitant use of celecoxib with other NSAIDs or salicylates is not recommended.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine