Compatibility «Paracetamol+Tramadol» and «Granisetrone»

• Interactions Paracetamol+Tramadol with Granisetrone

  • Negative interactions
    • ⓘ The withdrawal of serotonergic drugs causes a rapid disappearance of symptoms.
    • ⓘ Serotonergic drugs such as SSRI antidepressants, MAO inhibitors, anti-migraine drugs (triptans), linezolid (an antibiotic that is a reversible non-selective MAO inhibitor), as well as lithium preparations when combined with tramadol can cause serotonin syndrome.
    • ⓘ Concomitant use of tramadol with other serotonergic drugs such as SSRIs, SSRIs, MAO inhibitors, tricyclic antidepressants and mirtazapine may lead to the development of serotonin syndrome.
  • No interactions
    • ⓘ Granisetron does not affect the activity of cytochrome P450 isoenzymes CYP3A4 (responsible for the metabolism of some narcotic analgesics).
    • ⓘ No special studies have been conducted on the interaction with drugs for general anesthesia, but granisetron is well tolerated when administered simultaneously with similar drugs and narcotic analgesics.
  • Unclear interactions
    • ⓘ With serotonergic drugs such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SSRIs), MAO inhibitors, tricyclic antidepressants, mirtazapine.
    • ⓘ With antiemetics of the serotonin 5‑HT₃ receptor blocker group (for example, ondansetron).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,025,223 possible combinations of drugs and their components were found 412,561 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-12-11

Category - medicine