Compatibility «Supresta» and «Vitrum Plus Junior»

• Interactions Supresta with Vitrum Plus Junior

  • Negative interactions
    • ⓘ Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
    • ⓘ With prolonged use or use in high doses, the disulfiram-ethanol interaction may interfere.
    • ⓘ Antacids containing magnesium and aluminum hydroxides reduce absorption.
    • ⓘ When Mycophenolate mofetil-TL was co-administered with antacids (aluminum and magnesium hydroxide) and proton pump inhibitors (PPIs) (lansoprazole and pantoprazole), a decrease in the concentration of IFC was observed.
    • ⓘ This conclusion theoretically applies to antacids, since when they are taken simultaneously with Mycophenolate mofetil-TL, the concentration of IFC decreases to a much lesser extent than when taking Mycophenolate mofetil-TL with PPIs at the same time.
  • Unclear interactions
    • ⓘ It may affect the effectiveness of disulfiram in the treatment of chronic alcoholism.
    • ⓘ Absorption of vitamin B₁₂ may be impaired by the use of proton pump inhibitors (e.g. omeprazole), blockers of H₂-histamine receptors (e.g. cimetidine), colchicine, aminoglycosides (e.g. neomycin), aminosalicylic acid, antiepileptic drugs, salts potassium, methyldopa, as well as against the background of alcohol intake.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,032,480 possible combinations of drugs and their components were found 412,568 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-03-05

Category - medicine