Compatibility «Tenofovir» and «Velpatasvir+Sofosbuvir»
Between «Tenofovir» and «Velpatasvir+Sofosbuvir» found 9 negative and 4 positive interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Velpatasvir+Sofosbuvir |
✘Tenofovir Analogs | |
✘Velpatasvir+Sofosbuvir [Sofosbuvir] Analogs |
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Interactions Tenofovir with Velpatasvir+Sofosbuvir
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Negative interactions
The increase in tenofovir exposure (AUC and Cmax) was about 40-80% during the combined use of Epcluse and tenofovir disoproxil fumarate/emtricitabine in various HIV treatment regimens. Patients receiving tenofovir disoproxil fumarate and Epcluse simultaneously should be monitored for adverse reactions associated with tenofovir disoproxil fumarate. The combined use of Epcluse with efavirenz/emtricitabine/tenofovir disoproxil fumarate is expected to reduce the concentration of velpatasvir. Dose adjustment of Epcluse or emtricitabine/rilpivirine/tenofovir disoproxil fumarate is not required. Dose adjustment of Epcluse, atazanavir (ritonavir-enhanced) or emtricitabine/tenofovir disoproxil fumarate is not required. Dose adjustment of Epcluse, darunavir (ritonavir-enhanced) or emtricitabine/tenofovir disoproxil fumarate is not required. Dose adjustment of Epcluse, lopinavir (ritonavir-enhanced) or emtricitabine/tenofovir disoproxil fumarate is not required. Dose adjustment of Epcluse, raltegravir or emtricitabine/tenofovir disoproxil fumarate is not required. Dose adjustment of Epcluse or elvitegravir/cobicistat/emtricitabine / tenofovir disoproxil fumarate is not required. -
No interactions
When sofosbuvir is co-administered with tenofovir, dose adjustment of sofosbuvir or tenofovir is not required. In addition to the drugs listed above, interactions of sofosbuvir with the following drugs were evaluated in clinical trials, dose adjustment of which is not required: cyclosporine, darunavir/ritonavir, efavirenz, methadone, oral contraceptives, raltegravir, rilpivirine, tacrolimus and tenofovir disoproxil fumarate. -
Positive interactions
The Epcluse drug demonstrated increased exposure to tenofovir (inhibition of P-gp). Atazanavir, enhanced with ritonavir (300/100 mg 1 time per day) + emtricitabine/tenofovir disoproxil fumarate (200/300 mg 1 time per day). Darunavir, enhanced with ritonavir (800/100 mg 1 time per day) + emtricitabine/tenofovir disoproxil fumarate (200/300 mg 1 time per day)/. Lopinavir, enhanced with ritonavir (4×200 mg/50 mg 1 time per day + emtricitabine/tenofovir disoproxil fumarate (200/300 mg 1 time per day). -
Unclear interactions
ПРОТИВОВИРУСНЫЕ ПРЕПАРАТЫ ДЛЯ ЛЕЧЕНИЯ ВИЧ: ИНГИБИТОРЫ ОБРАТНОЙ ТРАНСКРИПТАЗЫ. Tenofovir disoproxil fumarate. instructions for the medical use of drugs containing tenofovir disoproxil fumarate for recommendations on monitoring kidney function (see 'Special instructions'). Efavirenz/emtricitabine/tenofovir disoproxil fumarate (600/200/300 mg 1 time per day)/velpatasvir/sofosbuvir (100/400 mg 1 time per day)c, d. Emtricitabine/ rilpivirine/tenofovir disoproxil fumarate (200/25/300 mg 1 time per day). ПРОТИВОВИРУСНЫЕ ПРЕПАРАТЫ ДЛЯ ЛЕЧЕНИЯ ВИЧ: ИНГИБИТОРЫ ПРОТЕАЗЫ ВИЧ. ПРОТИВОВИРУСНЫЕ ПРЕПАРАТЫ ДЛЯ ЛЕЧЕНИЯ ВИЧ: ИНГИБИТОРЫ ИНТЕГРАЗЫ. Raltegravir (400 mg 2 times a day)g + emtricitabine/tenofovir disoproxil fumarate (200/300 mg 1 time per day). Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (150/150/200/300 mg 1 time per day)/. Antiviral drugs for the treatment of HIV. Tenofovir, 300 mg 1 time per day. - Tenofovir. HIV protease inhibitors (70-143% equivalence limit). Tipranavir/ritonavir (HIV protease inhibitors).
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine