Compatibility «Digoxin» and «Diltiazem»
Between «Digoxin» and «Diltiazem» found 3 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
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Interactions Digoxin with Diltiazem
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Dangerous interactions
When taken simultaneously with antiarrhythmic drugs, beta-blockers, cardiac glycosides, bradycardia may develop, impaired atrioventricular conduction, and the appearance of symptoms of heart failure. Diltiazem increases the concentration of theophylline and carbamazepine in blood plasma (40-70%) and increases the risk of adverse reactions, including ataxia, nystagmus, diplopia, headache, vomiting, confusion, and also increases the concentrations of cyclosporine, digoxin (up to 50%), imipramine, lithium and midazolam. Diltiazem (C08DB01) + Cardiac glycosides (C01A) => The combined use of diltiazem with cardiac glycosides can cause atrioventricular conduction disorders, hypotension, bradycardia, heart failure. (With simultaneous urgent use of diltiazem and cardiac glycosides, the possibility of an inhibitory effect on the function of the sinus node should be considered. The combination of diltiazem with cardiac glycosides is potentially dangerous). -
Negative interactions
It is also known that calcium channel blockers have a depressing effect on sinoatrial and atrioventricular nodular conduction, especially diltiazem and verapamil. With simultaneous administration of diltiazem and digoxin, an increase in the concentration of digoxin in the blood is possible. -
No interactions
Nifedipine and diltiazem may or may not affect serum digoxin levels, while isradipine does not cause changes. -
Positive interactions
Calcium channel blockers may either increase or not cause changes in serum digoxin levels. Increases plasma levels of carbamazepine, theophylline, cyclosporine A, digoxin. Cimetidine increases the level of diltiazem in plasma, digoxin - potentiates the effectiveness in the tachysystolic form of atrial fibrillation.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine