Compatibility «Clindamycin» and «Kombinil-Duo»
Between «Clindamycin» and «Kombinil-Duo» found 6 negative and 1 positive interaction, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Kombinil-Duo |
✘Clindamycin Analogs | |
✘Kombinil-Duo [Dexamethasone and more 1Ciprofloxacin] Analogs |
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Interactions Clindamycin with Kombinil-Duo
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Negative interactions
When ciprofloxacin is combined with other antimicrobial drugs (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is usually observed; it can be successfully used in combination with azlocillin and ceftazidime in infections caused by Pseudomonas spp. Clindamycin is metabolized primarily with the participation of CYP3A4 and to a lesser extent CYP3A5 to form the main metabolite of clindamycin sulfoxide and the secondary metabolite N-desmethylclindamycin. Therefore, inhibitors of CYP3A4 and CYP3A5 can reduce, and inducers of these isoenzymes can increase the clearance of clindamycin. In vitro studies show that clindamycin does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2E1 or CYP2D6 and only moderately inhibits CYP3A4. The effectiveness of clindamycin should be carefully monitored in patients taking St. John's wort, a CYP3A4 inducer, together. Concomitant use of clindamycin (CYP3A4 substrate) and dexamethasone (CYP3A4 inducer) may increase clearance and lead to loss of clindamycin efficacy. -
Positive interactions
The activity increases when combined with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. -
Unclear interactions
With metronidazole and clindamycin - for anaerobic infections. In the presence of strong CYP3A4 inducers such as rifampicin, loss of efficacy must be controlled. Inhibitors of CYP3A4, CYP3A5. Inducers of CYP3A4, CYP3A5. Strong inducers of CYP3A4, such as rifampicin. Clindamycin.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine