Compatibility «Rosuvastatin» and «Velpatasvir+Sofosbuvir»

• Interactions Rosuvastatin with Velpatasvir+Sofosbuvir

  • Dangerous interactions
    • ⓘ Concomitant use with the combination of sofosbuvir + velpatasvir + voxilaprevir is contraindicated (see 'Contraindications').
    • ⓘ The combined use of Epcluse and rosuvastatin may increase the concentration of rosuvastatin, and thus increase the risk of myopathy, including rhabdomyolysis.
  • Negative interactions
    • ⓘ Ombitasvir 25 mg + paritaprevir 150 mg + ritonavir 100 mg + dasabuvir 400 mg 2 times a day, rosuvastatin 5 mg (single dose): an increase in max'>C_max and AUC of rosuvastatin by approximately 7.13 and 2.59 times when using three direct antiviral agents actions (3D) and 2.61 and 1.32 times of two direct-acting antiviral agents (2D).
    • ⓘ The combination of sofosbuvir 400 mg + velpatasvir 100 mg + voxilaprevir 100 mg (1 time per day, 15 days), rosuvastatin 10 mg (once): an increase in the AUC of rosuvastatin by approximately 7.39 times.
    • ⓘ Table 5, which provides examples of interactions with sensitive substrates P-gp (digoxin), BCRP (rosuvastatin) and OATP (pravastatin).
    • ⓘ When used in combination with Epcluse, a reduction in the dose of statins should be considered.
    • ⓘ Careful monitoring of adverse reactions associated with taking statins should also be carried out.
  • No interactions
    • ⓘ Interactions with other HMG-CoA reductase inhibitors cannot be excluded.
  • Unclear interactions
    • ⓘ HMG-CoA REDUCTASE INHIBITORS.
    • ⓘ Rosuvastatin.
    • ⓘ Rosuvastatin in a dose not exceeding 10 mg can be used with Epcluse.
    • ⓘ Rosuvastatin (10 mg once) /.
    • ⓘ Other statins.
    • ⓘ Statins.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,037,924 possible combinations of drugs and their components were found 412,574 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-07

Category - medicine