Compatibility «Clozapine» and «Depakine chronosphere»
Between «Clozapine» and «Depakine chronosphere» found 2 dangerous and 1 negative interaction, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Depakine chronosphere |
✘Clozapine Analogs | |
✘Depakine chronosphere [Valproic acid and more 1Valproate sodium] Analogs |
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Interactions Clozapine with Depakine chronosphere
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Dangerous interactions
Clozapine can enhance the central action of ethanol, MAO inhibitors and drugs that depress the central nervous system (such as drugs for anesthesia, H1‑histamine receptor blockers and benzodiazepines). Since clozapine can lower the seizure threshold, it may be necessary to adjust the dose of antiepileptic drugs. -
Negative interactions
Valproic acid can potentiate the effect of other psychotropic drugs such as neuroleptics, MAO inhibitors, antidepressants and benzodiazepines, therefore, when used simultaneously with valproic acid, careful medical supervision and, if necessary, dose adjustment is recommended. -
Unclear interactions
Neuroleptics, MAO inhibitors, antidepressants, benzodiazepines.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine